{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:49:28Z","timestamp":1781628568258,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870341"],"award-info":[{"award-number":["31870341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two new nervogenic acid derivatives liparisnervosides Q (<jats:bold>1<\/jats:bold>) and R (<jats:bold>5<\/jats:bold>), as well as five known nervogenic acid derivatives (<jats:bold>2<\/jats:bold>\u2013<jats:bold>4<\/jats:bold>, <jats:bold>6, 7<\/jats:bold>) and four phenanthrenes (<jats:bold>8<\/jats:bold>\u2013<jats:bold>11<\/jats:bold>) were isolated from the whole plant of <jats:italic>Liparis nervosa<\/jats:italic> (Thunb. ex A. Murray) Lindl.. Their structures were detremined using extensive spectroscopic techniques, including 1D, 2D NMR, and HR\u2010ESI\u2010MS, and acid hydrolysis. Furthermore, their antimicrobial and immunosuppressive activities were evaluated. Nervosine VII (<jats:bold>3<\/jats:bold>) exhibited antimicrobial activity against <jats:italic>Staphylococcus aureus<\/jats:italic> with an MIC of 62.5\u2005\u03bcg\/mL and inhibited the proliferation of human T cells with an IC<jats:sub>50<\/jats:sub> value of 9.67\u00b10.96\u2005<jats:italic>\u03bc<\/jats:italic>M. These findings contribute to our understanding of the potential pharmacological properties of these compounds.<\/jats:p>","DOI":"10.1002\/cbdv.202400721","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T13:20:08Z","timestamp":1713532808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nervogenic Acid Derivatives and Phenanthrenes from <i>Liparis nervosa<\/i> and Their Antimicrobial and Immunosuppressive Activities"],"prefix":"10.1002","volume":"21","author":[{"given":"Hong","family":"Jiang","sequence":"first","affiliation":[{"name":"College of Pharmacy, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai Tibet Plateau Southwest Minzu University  Chengdu 6 10041, China"},{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu 611137 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Chengdu Medical College  Chengdu 610500 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu 611137 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine Chengdu Medical College  Chengdu 610500 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu\u2010Lan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu 611137 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6595-1534","authenticated-orcid":false,"given":"Li\u2010Mei","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai Tibet Plateau Southwest Minzu University  Chengdu 6 10041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pld.2021.01.006"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.01.021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2020.104126"},{"key":"e_1_2_9_4_1","unstructured":"Editorial Committee of Flora of China Flora of China Science Press 1999 18 71."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2013.03.009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2016.01.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2018.06.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1328109"},{"key":"e_1_2_9_9_1","first-page":"1115","volume":"8","author":"Song Q.","year":"2013","journal-title":"Nat. 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