{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:14:14Z","timestamp":1789154054708,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the current investigation, a comprehensive analysis was carried out on essential oils (EOs) extracted from six aromatic plant species, namely <jats:italic>Rosmarinus officinalis<\/jats:italic>, <jats:italic>Pelargonium graveolens<\/jats:italic>, <jats:italic>Thymus vulgaris<\/jats:italic>, <jats:italic>Origanum vulgare, Laurus nobilis<\/jats:italic>, and <jats:italic>Aloysia citrodora<\/jats:italic>. An exploration was conducted into the chemical composition using Gas Chromatography\u2010Mass Spectrometry (GC\/MS), antioxidant properties assessed through DPPH, ABTS, CUPRAC, FRAP, MCA, and PBD assays, ecotoxicological impacts evaluated via allelopathy and the <jats:italic>Daphnia magna<\/jats:italic> heartbeat test, as well as bio\u2010pharmacological effects including anticancer activity and gene expression analysis. Results revealed strong antioxidant activity in all essential oils, with <jats:italic>T.\u2009vulgaris<\/jats:italic> EO (2748.00\u2005mg TE\/g) and <jats:italic>O.\u2005vulgare<\/jats:italic> EO (2609.29\u2005mg TE\/g) leading in CUPRAC assay. <jats:italic>R.\u2005officinalis<\/jats:italic> EO showed the highest \u03b1\u2010amylase inhibition at 1.58\u2005mmol ACAE\/g, while <jats:italic>O.\u2005vulgare<\/jats:italic> EO excelled in \u03b1\u2010glucosidase inhibition at 1.57\u2005mmol ACAE\/g. Additionally, cytotoxic effects were evaluated on human colorectal cancer (HCT116) cells. <jats:italic>A.\u2005citrodora, O.\u2005vulgare<\/jats:italic>, and <jats:italic>R.\u2005officinalis<\/jats:italic> EOs were found the most potent anticancer, as also witnessed by their higher modulatory effects on the gene expression of BAX and Bcl\u20102. Collectively, the present data highlight the importance to implement the knowledge and to valorize the supply chain of aromatic plants.<\/jats:p>","DOI":"10.1002\/cbdv.202400738","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T11:44:55Z","timestamp":1714650295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Combining the Pharmaceutical and Toxicological Properties of Selected Essential Oils with their Chemical Components by GC\u2010MS Analysis"],"prefix":"10.1002","volume":"21","author":[{"family":"Nilofar","sequence":"first","affiliation":[{"name":"Department of Pharmacy Botanic Garden \u201cGiardino dei Semplici\u201d, Universit\u00e0 degli Studi \u201cGabriele d'Annunzio\u201d  via dei Vestini\u200531 66100 Chieti Italy"},{"name":"Department of Biology Science Faculty, Selcuk University  42130 Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakeel","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Foodomics Laboratory Instituto de Investigaci\u00f3n en Ciencias de la Alimentaci\u00f3n CSIC-UAM  Nicol\u00e1s Cabrera\u20059 28049 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology Science Faculty, Selcuk University  42130 Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta Cristina","family":"Di Simone","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Botanic Garden \u201cGiardino dei Semplici\u201d, Universit\u00e0 degli Studi \u201cGabriele d'Annunzio\u201d  via dei Vestini\u200531 66100 Chieti 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