{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:41:16Z","timestamp":1789821676630,"version":"4.0.1"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Herein, we report analogues of\n                    <jats:italic>s<\/jats:italic>\n                    \u2010indacene by the synthesis of novel indolizine derivatives. Using chloroform as an appropriate solvent, sixteen derivatives of pyrazolyl\u2010indolizine (\n                    <jats:bold>4\u2010<\/jats:bold>\n                    \u2010\n                    <jats:bold>19<\/jats:bold>\n                    ) were prepared by the reaction of 3\u2010(dimethylamino)\u20101\u2010(1\n                    <jats:italic>H<\/jats:italic>\n                    \u2010pyrrol\u20102\u2010yl)prop\u20102\u2010en\u20101\u2010one (\n                    <jats:bold>1<\/jats:bold>\n                    ) with hydrazonoyl chloride derivatives (\n                    <jats:bold>2<\/jats:bold>\n                    ) in the presence of triethylamine in good to excellent yields. We used NMR spectra, IR, mass spectrometry, as well as elemental analyses to prove the chemical structures and the purity of the synthesized compounds\n                    <jats:bold>4<\/jats:bold>\n                    \u2013\n                    <jats:bold>19<\/jats:bold>\n                    . Among all tested compounds\n                    <jats:bold>5<\/jats:bold>\n                    ,\n                    <jats:bold>9<\/jats:bold>\n                    ,\n                    <jats:bold>13<\/jats:bold>\n                    and\n                    <jats:bold>19<\/jats:bold>\n                    had a potent antimicrobial efficiency against\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    ,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aerginousea<\/jats:italic>\n                    ,\n                    <jats:italic>Sallmonella typhemerium<\/jats:italic>\n                    , and\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    . Furthermore, a significant increase in lipid peroxidation (LPO) toward the Gram\u2010negative bacteria,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    when treated with compound\n                    <jats:bold>9<\/jats:bold>\n                    was observed, while compound\n                    <jats:bold>13<\/jats:bold>\n                    remarkably increased the cell membrane oxidation of\n                    <jats:italic>Salmonella typhimurium<\/jats:italic>\n                    . Additionally, we utilized docking studies and\n                    <jats:italic>in silico<\/jats:italic>\n                    methods to evaluate the drug\u2010likeness, physicochemical properties, and ADMET profiles of the compounds. The results of the molecular docking simulation revealed that the synthesized compounds displayed decreased binding energy when interacting with the active sites of important enzymes, including Sterol 14\u2010demethylase of C. albicans, Dihydropteroate synthase of\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , LasR of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    , Glucosamine\u20106\u2010phosphate synthase of\n                    <jats:italic>S. typhimurium<\/jats:italic>\n                    , and Gyrase B of\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202400825","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T22:25:08Z","timestamp":1716848708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of Pyrazolyl\u2010Indolizine Derivatives as Antimicrobial Agents: Synthesis,\n                    <i>In vitro<\/i>\n                    ,\n                    <i>In silico<\/i>\n                    ADMET and Molecular Docking Studies"],"prefix":"10.1002","volume":"21","author":[{"given":"Shorouk S.","family":"Mukhtar","sequence":"first","affiliation":[{"name":"Organometallic and Organometalloid Chemistry Department National Research Centre  12622 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-2157","authenticated-orcid":false,"given":"Farid M.","family":"Sroor","sequence":"additional","affiliation":[{"name":"Organometallic and Organometalloid Chemistry Department National Research Centre  12622 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taghrid S.","family":"Hafez","sequence":"additional","affiliation":[{"name":"Organometallic and Organometalloid Chemistry Department National Research Centre  12622 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdelraof","sequence":"additional","affiliation":[{"name":"Microbial Chemistry Department Biotechnology Research Institute National Research Centre  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed F.","family":"El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Microbial Genetics Department Biotechnology Research Institute National Research Centre  Giza Egypt"},{"name":"Egypt Center for Research and Regenerative Medicine (ECRRM)  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara N.","family":"Laboud","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdi M.","family":"Hassaneen","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma M.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"e_1_2_8_1_1","volume":"12","author":"Costa R. 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