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LC\u2010ESI\u2010MS spectrometry was the hyphenated tool for component identification of these extracts. Behavioral, biochemical, and histopathological investigations were carried out after treatments of diabetic rats. The phenolic contents in the extracts are 16.38, 34.75 and 40.57\u2005mg GAE\/g extract regarding\n                    <jats:italic>A. esculentus<\/jats:italic>\n                    leaves\n                    <jats:italic>, M. nigra<\/jats:italic>\n                    leaves and\n                    <jats:italic>P. granatum<\/jats:italic>\n                    peel respectively. Chemodiversity of the phenolic contents was observed from the LC\/Mass, where\n                    <jats:italic>A. esculentus<\/jats:italic>\n                    extract contained isoflavonoids and flavanones,\n                    <jats:italic>M. nigra<\/jats:italic>\n                    extract consisted of benzofurans, prenylated flavonoids, stilbenes, and xanthones, and\n                    <jats:italic>P. granatum<\/jats:italic>\n                    extract was rich in ellagitanins, condensed tannins, and anthocyanins. The extracts normalize of blood glucose levels, enhance the explorative behavior of the rats and their response time to thermal pain, restore the oxidant\/antioxidant balance, attenuate inflammation, augment brain monoamines levels and modulate MAO\u2212A and Ache enzyme activity. Furthermore, they recovered brain histopathological alterations. Conclusively, this study offers experimental evidence for the neuroprotective impact of studied defatted ethanol extracts against diabetic neuropathy\n                    <jats:italic>via<\/jats:italic>\n                    their hypoglycemic effect, antioxidant activity, and anti\u2010inflammatory potential.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202400843","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T07:38:23Z","timestamp":1723621103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chemical Profile and Potential Application of Agri\u2010food Waste Products for Counteracting Diabetes Induced Neuropathy in Rats"],"prefix":"10.1002","volume":"21","author":[{"given":"Sahar S.","family":"El Souda","sequence":"first","affiliation":[{"name":"Chemistry of Natural Compounds Department National Research Centre  33 El Buhouth St Giza, Dokki P.O.12622 (ID: 60014618), Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa H.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Hormones Department Medical Research and Clinical Studies Institute National Research Centre  Giza, Dokki Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal A.","family":"Maamoun","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department National Research Centre  33 El Buhouth St Cairo, Giza, Dokki P.O.12622 (ID:60014618) Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza A.","family":"Matloub","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department National Research Centre  33 El Buhouth St Cairo, Giza, Dokki P.O.12622 (ID:60014618) Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-0172","authenticated-orcid":false,"given":"Hadeer A.","family":"Aglan","sequence":"additional","affiliation":[{"name":"Hormones Department Medical Research and Clinical Studies Institute National Research Centre  Giza, Dokki Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"issue":"7","key":"e_1_2_10_1_1","volume":"14","author":"Abouzid M. 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