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By diazotizing (4\u2010arylazo\u20103\u2010hydroxy\u20102\u2010thienyl) 4\u2010antipyrine ketones <jats:bold>1a<\/jats:bold>, <jats:bold>1b<\/jats:bold> and <jats:bold>1c<\/jats:bold> and (4\u2010arylazo\u20103\u2010methyl\u20102\u2010thienyl) 4\u2010antipyrine ketones (<jats:bold>2a<\/jats:bold>, <jats:bold>2b<\/jats:bold> and <jats:bold>2c<\/jats:bold>) further replaced with six other coupling components, a broad spectrum of hybrid molecules have been created. Mass spectra, NMR, FTIR, and elemental analyses have all been used to confirm the structures of the synthesised compounds. The antimicrobial screening was investigated by agar well diffusion and diluting the broth technique against both Gram\u2010negative and positive\u2010tested bacterial strains. (3\u2010methyl\u20105\u2010(phenylamino)\u20104\u2010(4\u2010tolylazo)\u20102\u2010thienyl) 4\u2010antipyrine ketone (<jats:bold>2a<\/jats:bold>) was found to be superior to Ciprofloxacin against test strains: <jats:italic>Acinetobacter<\/jats:italic> sp (34.33\u00b11.15\u2005mm), <jats:italic>Listeria monocytogenes<\/jats:italic> (29.33\u00b11.15\u2005mm) and <jats:italic>Streptococcus<\/jats:italic> sp. (19.33\u00b11.15 mm). Also, good to moderate activities were expressed as minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC) which were recorded at 9\u00b11 to 59.67\u00b14.51\u2005\u03bcg\/mL and 16\u00b14 to &gt;512\u2005\u03bcg\/mL, respectively, using compounds <jats:bold>2a<\/jats:bold>, <jats:bold>2b<\/jats:bold>, and <jats:bold>2c<\/jats:bold>. MBC\/MIC ratio showed, that only, <jats:bold>2a<\/jats:bold> and <jats:bold>2b<\/jats:bold> have a bactericidal effect but other antipyrines with bacteriostatic strength. To conclude, it was suggested that the use of these novel synthesized (4\u2010arylazo\u20103\u2010methyl\u20102\u2010thienyl) 4\u2010antipyrine ketone derivatives molecules as a new chemical class of antimicrobial agents to perform new drug discovery in pharmaceutical preparations and medicinal research.<\/jats:p>","DOI":"10.1002\/cbdv.202400894","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T14:40:13Z","timestamp":1716561613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design, Synthesis and Antibacterial Assessment of Active (4\u2010Arylazo\u20103\u2010Methyl\u20102\u2010Thienyl) 4\u2010Antipyrine Ketones"],"prefix":"10.1002","volume":"21","author":[{"given":"Khouloud M.","family":"Barakat","sequence":"first","affiliation":[{"name":"National Institute of Oceanography and Fisheries (NIOF)  Kayet Bey, Elanfoushy Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shymaa","family":"Adel Elsayed","sequence":"additional","affiliation":[{"name":"National Institute of Oceanography and Fisheries (NIOF)  Kayet Bey, Elanfoushy Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Osmaniye Korkut Ata University Bah\u00e7e Vocational School Department of Chemistry and Chemical Processing Technologies  Osmaniye 80000 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab","family":"Abdel\u2010Latif","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Mansoura University  ET 35516 Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan Ali","family":"Etman","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Mansoura University  ET 35516 Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Hamed","sequence":"additional","affiliation":[{"name":"National Institute of Oceanography and Fisheries (NIOF)  Kayet Bey, Elanfoushy Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2373-5846","authenticated-orcid":false,"given":"Ahmed","family":"El Nemr","sequence":"additional","affiliation":[{"name":"National Institute of Oceanography and Fisheries (NIOF)  Kayet Bey, Elanfoushy Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.739"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009935116877"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.01.043"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.02.036"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jccs.201900374"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2010.00948.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10406638.2021.1886127"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2016.10.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC05304A"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jccs.201800405"},{"key":"e_1_2_9_11_1","first-page":"11","volume":"3","author":"Fadda A. 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