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For the first time, we examined antioxidant and antimicrobial activity of 70\u2009%\u2005v\/v methanolic extracts from inflorescences and roots of <jats:italic>Cirsium monspessulanum<\/jats:italic> (L.) Hill. obtained by the ASE method. In the (2,2\u2010diphenyl\u20101\u2010picrylhydrazyl) DPPH analysis, tested extract of inflorescences showed antioxidant activity with an EC<jats:sub>50<\/jats:sub>=0.223\u00b10.0479\u2005mg\/mL, and (Cupric Ion Reducting Antioxidant Capacity) CUPRAC test assessed the antiradical activity on 14.95\u00b10.13\u2005mgTE\/g and for roots the values were EC<jats:sub>50<\/jats:sub>=0.307\u00b10.0554\u2005mg\/mL and 11.18\u00b10.49\u2005mgTE\/g, respectively. Furthermore, extract from the inflorescences possessed the highest antimicrobial activity against <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Staphylococcus epidermidis<\/jats:italic> and <jats:italic>Micrococcus luteus<\/jats:italic> with MIC=1.25\u2005mg\/mL for each. HPLC\/ESI\u2010QTOF\u2010MS\/MS method identified 7 phenolic acids and 14 flavonoids in inflorescences extract and only 7 phenolic acids in roots extract. To the best of our knowledge, this is the first qualitative analysis of <jats:italic>Cirsium monspessulanum<\/jats:italic> (L.) Hill. and all substances were described for the first time.<\/jats:p>","DOI":"10.1002\/cbdv.202400944","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T11:09:39Z","timestamp":1717412979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phytochemical Profiling and Biological Activity of the Methanolic Extracts of <i>Cirsium Monspessulanum<\/i> (L.) 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