{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:27:33Z","timestamp":1775881653717,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genus Asparagus is well known for its pharmacological activities and ethnopharmacological applications. In folk medicine, it is used in the management of several diseases such as diabetes, inflammations, and rheumatism. This work aimed to investigate the potential of <jats:italic>Asparagus densiflorus meyeri<\/jats:italic> root &amp; aerial parts extracts as cytotoxic and anti\u2010inflammatory and the investigation of their chemical profile. GC analysis &amp; Folin\u2010Ciocalteu and gravimetric methods were used respectively to estimate the lipoidal, phenolic, and saponin contents. MTT assay was conducted using two cell lines (MCF\u20107 &amp; HepG2) to investigate the cytotoxic and anti\u2010inflammatory activity using TNF\u2010\u03b1 stimulated MCF\u20107 cells through monitoring the level of nitric oxide release and NF\u2010\u03baB gene expression. Preliminary phytochemical investigation indicated that both extracted parts are equally rich in saponins, flavonoids, carbohydrates and\/or glycosides, and sterols and\/or triterpenes. Palmitic acid and <jats:italic>\u03b2<\/jats:italic> sitosterol represented the major saturated fatty acids and sterol, respectively. A significant cytotoxic activity against MCF\u20107 cells was recorded for DCM extract (IC<jats:sub>50<\/jats:sub> 26.13\u2005\u03bcg\/ml). All tested extracts showed a significant decrease in NO release and NF\u2010\u03baB gene expression thus it possesses a potential anti\u2010inflammatory activity. <jats:italic>A. densiflorus meyeri<\/jats:italic> is considered a good candidate as a food supplement for protection from malignancy.<\/jats:p>","DOI":"10.1002\/cbdv.202400959","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:11:42Z","timestamp":1722330702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>In\u2010Vitro<\/i> Cytotoxic and Anti\u2010Inflammatory Potential of <i>Asparagus Densiflorus Meyeri<\/i> and its Phytochemical Investigation"],"prefix":"10.1002","volume":"21","author":[{"given":"Yasmin","family":"Sobhy","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Helwan University  Ain Helwan, Cairo 11795 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6095-1081","authenticated-orcid":false,"given":"Shahenda","family":"Mahgoub","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Faculty of Pharmacy Helwan University  Ain Helwan, Cairo 11795 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1651-7421","authenticated-orcid":false,"given":"Yasmin","family":"Abo\u2010zeid","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy Helwan University  Ain Helwan, Cairo 11795 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9826-938X","authenticated-orcid":false,"given":"Suzan A.","family":"Mina","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Helwan University  Ain Helwan, Cairo 11795 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-0442","authenticated-orcid":false,"given":"Mohamed S.","family":"Mady","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Helwan University  Ain Helwan, Cairo 11795 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920008785821657"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2017.06.027"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21101326"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2020.04.016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3828"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-03170-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.49"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2519"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.07.014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00087114.1959.10797078"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.103727"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-8478cr20180863"},{"key":"e_1_2_9_13_1","first-page":"7","volume":"12","author":"Onlom C N.","year":"2017","journal-title":"Nat. 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