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Currently, the available vaccines\/drugs have posed profound toxicity and limited efficacy leading to limited therapeutic options. Herein, our study sheds light on a novel anti\u2010dengue agent made of lipidic phytocompounds extracted from\n                    <jats:italic>Breynia vitis\u2010idaea<\/jats:italic>\n                    leaves, which were isolated and analyzed for their larvicidal potential against the\n                    <jats:italic>Aedes<\/jats:italic>\n                    mosquito. The isolated prime compounds, namely, eicosanic acid ethyl ester and ethyl 3\u2010methylpentanoate were characterized using UV, FT\u2010IR, mass,\n                    <jats:sup>1<\/jats:sup>\n                    H, and\n                    <jats:sup>13<\/jats:sup>\n                    C NMR spectroscopic techniques to confirm their molecular structures. The structural orientation was performed using the B3LYP\/cc\u2010pVDZ basis set method. The effectiveness of the isolated compounds and their inhibitory mechanisms against\n                    <jats:italic>Aedes<\/jats:italic>\n                    methyl transferase\u2010converting enzyme (MTase) were investigated by in silico studies and proven to be of significant binding potential with a key molecular target, acetylcholinesterase (AChE), for mosquitocides and dengue methyltransferase. Molecular dynamics simulation studies further confirmed the stability of the complexes. The present work certainly enables the development of promising larvicidal molecules from plant resources as an alternative drug for treating\n                    <jats:italic>Aedes<\/jats:italic>\n                    mosquitoes.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401003","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T20:43:40Z","timestamp":1752266620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Characterization, Computational, and Molecular Docking of Lipids Isolated From\n                    <i>Breynia vitis\u2010idaea<\/i>\n                    Leaves: Potential Compounds Against\n                    <i>Aedes<\/i>\n                    Mosquito"],"prefix":"10.1002","volume":"22","author":[{"given":"Jeyasankar","family":"Alagarmalai","sequence":"first","affiliation":[{"name":"Department of Zoology Government Arts College (Autonomous)  Coimbatore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beutline","family":"Malgija","sequence":"additional","affiliation":[{"name":"Centre for Computational Informatics, MCC\u2010MRF Innovation Park, Madras Christian College  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Elangovan","sequence":"additional","affiliation":[{"name":"Arignar Anna Government Arts College Bharathidasan University  Tiruchirappalli Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perumal Samy","family":"Ramar","sequence":"additional","affiliation":[{"name":"Department of Anatomy Yong Loo Lin School of Medicine, National University of Singapore National University Health System (NUHS)  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannet Vennila","family":"James","sequence":"additional","affiliation":[{"name":"Centre for Computational Informatics, MCC\u2010MRF Innovation Park, Madras Christian College  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3405-6208","authenticated-orcid":false,"given":"Jebasingh","family":"Bhagavathsingh","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry Karunya Institute of Technology and Sciences  Coimbatore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"\u201cTransmission through the mosquito bite \u201d World Health Organization accessed July 04 2025 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/dengue\u2010and\u2010severe\u2010dengue."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.55"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_2_8_5_1","unstructured":"European Centre for Disease Prevention and Control \u201cDengue Worldwide Overview 2019 \u201d accessed January 4 2020 https:\/\/www.ecdc.europa.eu\/en\/dengue\u2010monthly."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.10.012"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.52155\/ijpsat.v6.1.190"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201003854\u2010z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010virology\u2010110615\u2010042334"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2020.08.053"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9010042"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aspen.2010.02.001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17020144"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12021089"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.13040\/IJPSR.0975\u20108232"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.610912"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20107622\u20102\u20101"},{"key":"e_1_2_8_18_1","volume-title":"Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis","author":"Harborne J. 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