{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:54:29Z","timestamp":1792371269689,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Phytochemical investigation of the methanol extract of the aerial parts of\n                    <jats:italic>Lysimachia laxa<\/jats:italic>\n                    led to the isolation of four new oleanane\u2010\n                    <jats:italic>type<\/jats:italic>\n                    saponins, lysimosides A\u2013D (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    ) and one known compound, lysimachigenoside B (\n                    <jats:bold>5<\/jats:bold>\n                    ). Their structures were elucidated using a combination of HR\u2010ESI\u2010MS, 1D and 2D\u2010NMR spectral data, chemical methods, and comparison with previous literature. The cytotoxic activity of these compounds was evaluated against human lung cancer (A\u2010549) and human breast cancer (MCF\u20107) cell lines. All compounds exhibited cytotoxic activity against A\u2010549 and MCF\u20107\u2005cell lines with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 6.1\u201316.0\u2005\u03bcM, comparable to the positive control, mitoxantrone. Interestingly, oleanane\u2010\n                    <jats:italic>type<\/jats:italic>\n                    saponins with an acetyl group (\n                    <jats:bold>2<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    ) exhibited increased cytotoxic activities compared to those without an acetyl group (\n                    <jats:bold>1<\/jats:bold>\n                    ).\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401024","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T08:54:23Z","timestamp":1724403263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cytotoxic Effects of Oleanane\u2010\n                    <i>type<\/i>\n                    Saponins from\n                    <i>Lysimachia laxa<\/i>"],"prefix":"10.1002","volume":"21","author":[{"given":"Le Thi","family":"Huyen","sequence":"first","affiliation":[{"name":"VNU University of Science Vietnam National University, Hanoi  334 Nguyen Trai Thanh Xuan, Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dang Gia","family":"Bao","sequence":"additional","affiliation":[{"name":"Nguyen Hue High School for Gifted  560B Quang Trung Ha Dong, Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi","family":"Son","sequence":"additional","affiliation":[{"name":"VNU University of Science Vietnam National University, Hanoi  334 Nguyen Trai Thanh Xuan, Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Van","family":"Anh","sequence":"additional","affiliation":[{"name":"VNU University of Science Vietnam National University, Hanoi  334 Nguyen Trai Thanh Xuan, Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bui Huu","family":"Tai","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet Cau Giay, Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan Thi Thanh","family":"Huong","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet Cau Giay, Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan Van","family":"Kiem","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet Cau Giay, Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Kim","family":"Thuy","sequence":"additional","affiliation":[{"name":"Center for High Technology Research and Development VAST  18 Hoang Quoc Viet Cau Giay, Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi","family":"Hanh","sequence":"additional","affiliation":[{"name":"Center for High Technology Research and Development VAST  18 Hoang Quoc Viet Cau Giay, Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SeonJu","family":"Park","sequence":"additional","affiliation":[{"name":"Metropolitan Seoul Center Korea Basic Science Institute  Seoul 03579 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1161-6498","authenticated-orcid":false,"given":"Nguyen Xuan","family":"Nhiem","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet Cau Giay, Hanoi Viet Nam"},{"name":"Graduate University of Science and Technology VAST  18 Hoang Quoc Viet Cau Giay, Hanoi Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"1","volume":"7","author":"Gupta S.","year":"2017","journal-title":"3 Biotech"},{"key":"e_1_2_7_2_1","first-page":"33","volume":"5","author":"Gupta S.","year":"2013","journal-title":"J. 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