{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:08:59Z","timestamp":1782191339463,"version":"3.54.5"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This work aims to describe the morpho\u2010anatomy and determine the mineral composition of <jats:italic>H. muticus<\/jats:italic> L. subsp. <jats:italic>falezlez<\/jats:italic> seed, and investigate the influence of extraction solvents (hexane, petroleum ether, chloroform and methanol) on contents of total phenolic (TPC) and flavonoid (TFC) and the antioxidant activity (DPPH, ABTS, reducing power and phenanthroline). The mineral content analysis revealed the presence of different elements. The results indicated that the seed extract obtained by methanol exhibited the highest yield and TPC (82.07\u2009% and 27.14\u00b12.2\u2005\u03bcg\u2009GAE\/mg), while the chloroform extract had the maximum TFC (24.63\u00b10.4\u2005\u03bcg\u2009QE\/mg). In addition, all seed extracts showed excellent performances on DPPH scavenging activity. However, methanolic extract was the most effective extraction solvent for scavenging ABTS free radicals (IC<jats:sub>50<\/jats:sub>&lt;12.5\u2005\u03bcg\/mL). Chloroform and petroleum ether extracts were the most potent in phenanthroline activity. GC\u2010MS analysis identified 28 phytochemical compounds in all extracts and 16 compounds were identified by HPLC\/DAD analysis of the methanolic extract. The multivariate analysis results highlighted the influence of solvents on the phenolic composition and antioxidant activity of seed extracts. The results suggest that <jats:italic>H. muticus<\/jats:italic> L. seeds can be a promising source enriched with bioactive constituents for application in the pharmaceutical industry.<\/jats:p>","DOI":"10.1002\/cbdv.202401026","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T13:30:04Z","timestamp":1719667804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Seeds of <i>Hyoscyamus muticus<\/i> L. subsp. <i>falezlez<\/i>: Morpho\u2010Anatomical Features, Phytochemical Investigation and Evidence for Antioxidant Activities"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0664-7302","authenticated-orcid":false,"given":"Sofia","family":"Ayari\u2010Guentri","sequence":"first","affiliation":[{"name":"D\u00e9partement des Sciences de la Nature et de la Vie Facult\u00e9 des Sciences Universit\u00e9 d'Alger 1  Benyoucef Benkhedda, 02. 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