{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T19:03:15Z","timestamp":1784055795678,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204240"],"award-info":[{"award-number":["82204240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Four new clerodane diterpenoids, namely tinocapills A\u2013D (<jats:bold>1<\/jats:bold>\u2013<jats:bold>4<\/jats:bold>), and one known analogue (<jats:bold>5<\/jats:bold>) were isolated from the roots of <jats:italic>Tinospora capillipes<\/jats:italic> in the present study. The structures of these new compounds, including their absolute configurations, were determined through a combination of detailed spectroscopic analysis and theoretical statistical approaches, including electronic circular dichroism (ECD) analyses and quantum mechanical (QM)\u2010NMR methods. Additionally, the stereostructure of <jats:bold>5<\/jats:bold> was confirmed via X\u2010ray diffraction analysis. Furthermore, all these isolates were evaluated for their antibacterial and anti\u2010inflammatory activities. Compounds <jats:bold>1<\/jats:bold>, <jats:bold>2<\/jats:bold> and <jats:bold>5<\/jats:bold> demonstrated antibacterial activity against methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) with MICs ranging from 4\u201364\u2005<jats:italic>\u03bcg\/mL<\/jats:italic>, and compounds <jats:bold>3<\/jats:bold> and <jats:bold>4<\/jats:bold> exhibited potential anti\u2010inflammatory effects by suppressing LPS\u2010induced TNF\u2010\u03b1 and NO releases in RAW264.7 cells.<\/jats:p>","DOI":"10.1002\/cbdv.202401033","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T02:14:59Z","timestamp":1719800099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["New Clerodane Diterpenoids from <i>Tinospora Capillipes<\/i> with Antibacterial and Anti\u2010Inflammatory Properties"],"prefix":"10.1002","volume":"21","author":[{"given":"Yuan\u2010Ze","family":"Song","sequence":"first","affiliation":[{"name":"Zibo Hospital of Traditional Chinese Medicine  Zibo 255000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Zoucheng Administration for Market Regulation  Zoucheng 273100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical laboratory,Disease Prevention and Control Center of Yanzhou District  Jining 272100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Jiang","family":"Song","sequence":"additional","affiliation":[{"name":"Zibo Hospital of Traditional Chinese Medicine  Zibo 255000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Hao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Zibo Hospital of Traditional Chinese Medicine  Zibo 255000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-8630","authenticated-orcid":false,"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology University of Jinan  Jinan 250022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"361","volume":"71","author":"Maurya R.","year":"1994","journal-title":"J. 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