{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:30:43Z","timestamp":1768354243778,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Four undescribed spirostan glycosides, (25<jats:italic>S<\/jats:italic>)\u20105<jats:italic>\u03b1<\/jats:italic>\u2010spirostan\u2010 12\u2010one\u20102<jats:italic>\u03b1<\/jats:italic>,3<jats:italic>\u03b2<\/jats:italic>\u2010diol\u20103\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl\u2010(1\u21924)\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010galactopyranoside (<jats:bold>1<\/jats:bold>), (25<jats:italic>S<\/jats:italic>)\u20105<jats:italic>\u03b1<\/jats:italic>\u2010spirostan\u201012\u2010one\u20102<jats:italic>\u03b1<\/jats:italic>,3<jats:italic>\u03b2<\/jats:italic>\u2010diol\u20103\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010galatopyranosyl\u2010(1\u21922)\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl\u2010 (1\u21924)\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010galactopyranoside (<jats:bold>2<\/jats:bold>), (25<jats:italic>S<\/jats:italic>)\u20105<jats:italic>\u03b1<\/jats:italic>\u2010spirostan\u201012\u2010one\u20102<jats:italic>\u03b1<\/jats:italic>,3<jats:italic>\u03b2<\/jats:italic>\u2010diol\u20103\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl\u2010(1\u21922)\u2010[<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl\u2010(1\u21923)]\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl\u2010(1\u21924)\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010galactopyranoside (<jats:bold>3<\/jats:bold>), and hecogenin 3\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl\u2010(1\u21923)\u2010[<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010xylopyranosyl\u2010(1\u21922)]\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranosyl\u2010(1\u21924)\u2010[<jats:italic>\u03b1<\/jats:italic>\u2010L\u2010rhamnopyranosyl\u2010(1\u21922)]\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010galactopyranoside (<jats:bold>4<\/jats:bold>), together with eleven known compounds (<jats:bold>5<\/jats:bold>\u2013<jats:bold>15<\/jats:bold>) were isolated from the branches and leaves of <jats:italic>Tribulus terrestris<\/jats:italic>. Their chemical structures were established through spectroscopic methods, including HR\u2010ESI\u2010MS, 1D\u2010, and 2D\u2010NMR spectra. Preliminary biological evaluation on NO production inhibitory activity in LPS activated RAW 264.7\u2005cells showed that compounds\u2005<jats:bold>1<\/jats:bold>\u2013<jats:bold>3<\/jats:bold>, <jats:bold>5<\/jats:bold>, and <jats:bold>6<\/jats:bold> had significant inhibitory effects with IC<jats:sub>50<\/jats:sub> values ranging from 2.4 to 18.3\u2005\u03bcM, compared to that of the positive control compound, dexamethazone (IC<jats:sub>50<\/jats:sub> 13.6\u2005\u03bcM).<\/jats:p>","DOI":"10.1002\/cbdv.202401049","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T03:44:40Z","timestamp":1715917480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tributelosides A\u2212D: Four Undescribed Spirostan Glycosides Isolated from the Branches and Leaves of <i>Tribulus terrestris<\/i> with Their NO Production Inhibitory Activity in LPS Activated RAW 264.7 Cells"],"prefix":"10.1002","volume":"21","author":[{"given":"Nguyen","family":"Van Quoc","sequence":"first","affiliation":[{"name":"School of chemistry biology and environment Vinh University  182 Le Duan, Ben Thuy Vinh City Nghe An 461010 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Huy Hoang","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui","family":"Huu Tai","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pham","family":"Hai Yen","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Thi Cuc","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan Thi","family":"Thanh Huong","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duong","family":"Thi Dung","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do","family":"Thi Trang","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"The Cuong","sequence":"additional","affiliation":[{"name":"Institute of Ecology and Biological Resources  VAST, 18 Hoang Quoc Viet Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Duc Giang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Vinh University, 182 Le Duan, Ben Thuy  Vinh City Nghe An 461010 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-6990","authenticated-orcid":false,"given":"Phan","family":"Van Kiem","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST  18 Hoang Quoc Viet Cau Giay Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_11_1_1","first-page":"999","volume-title":"The Dictionary of Vietnamese Medicinal Plants","author":"Chi V. 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