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The present study aimed to investigate the phytochemical composition and biological activities of the rhizomes of <jats:italic>K. parviflora<\/jats:italic>. The ethanol crude and fractionated extracts (hexane and chloroform) of the rhizomes were evaluated for their total phenolic content, total steroidal content, as well as antioxidant, anti\u2010obesogenic, and anti\u2010diabetic activities. The chloroform extract demonstrated the highest concentration of plant sterols (432\u00b10.23\u2005mg BSE\/g extract) and a substantial amount of phenolic compounds (1.19\u00d710<jats:sup>3<\/jats:sup>\u00b10.41\u2005mg GAE\/g extract). Gas chromatography\u2010mass spectrometry (GC\/MS) analysis revealed that the chloroform extract of the rhizomes is predominantly composed of bioactive flavonoids including tectochrysin (<jats:bold>1<\/jats:bold>), 5,7\u2010dimethoxyflavone (<jats:bold>2<\/jats:bold>), 3,5,7\u2010trimethoxyflavone (<jats:bold>3<\/jats:bold>), 3,4\u2019,5,7\u2010tetramethoxyflavone (<jats:bold>4<\/jats:bold>), and 4\u2019,5,7\u2010trimethoxyflavone (<jats:bold>5<\/jats:bold>). Furthermore, the chloroform extract exhibited the highest overall radical scavenging and \u03b1\u2010glucosidase inhibitory activities, which can be attributed to the presence of compounds <jats:bold>1<\/jats:bold>\u2013<jats:bold>5<\/jats:bold> in the extract. Collectively, these findings suggest that the chloroform extract of the rhizomes of <jats:italic>K. parviflora<\/jats:italic> is a potentially valuable source of bioactive compounds with antioxidant, anti\u2010obesogenic, and anti\u2010diabetic properties, with potential application in therapeutics and functional foods.<\/jats:p>","DOI":"10.1002\/cbdv.202401086","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T04:49:24Z","timestamp":1726634964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Investigation of Phytochemical Composition, Radical Scavenging Potential, Anti\u2010Obesogenic Effects, and Anti\u2010Diabetic Activities of <i>Kaempferia parviflora<\/i> Rhizomes"],"prefix":"10.1002","volume":"22","author":[{"given":"Sangeetha","family":"Prabakaran","sequence":"first","affiliation":[{"name":"Institute of Biological Sciences Faculty of Science Universiti Malaya  50603 Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8676-4604","authenticated-orcid":false,"given":"Hazwani Mat","family":"Saad","sequence":"additional","affiliation":[{"name":"Biology Division Centre for Foundation Studies in Science Universiti Malaya  50603 Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1730-6650","authenticated-orcid":false,"given":"Chun Hoe","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Faculty of Applied Sciences Lincoln University College  47301 Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syarifah Nur","family":"Syed Abdul Rahman","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniofacial Sciences Faculty of Dentistry Universiti Malaya  50603 Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-1621","authenticated-orcid":false,"given":"Kae Shin","family":"Sim","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences Faculty of Science Universiti Malaya  50603 Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.02.008"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-417205-0.00005-5"},{"key":"e_1_2_9_3_1","first-page":"1250","volume":"24","author":"Croteau R.","year":"2000","journal-title":"Biochem. 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