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In present study, eight new labdane\u2010type diterpenoids, crotonoids A\u2013H (<jats:bold>1<\/jats:bold>\u2013<jats:bold>8<\/jats:bold>) and one known analogue (<jats:bold>9<\/jats:bold>) were isolated from the aerial parts of <jats:italic>C. sublyratus<\/jats:italic>. Compounds <jats:bold>6<\/jats:bold> and <jats:bold>7<\/jats:bold> belong to the rare class of 14,15\u2010<jats:italic>dinor<\/jats:italic>\u2010labdane diterpenoids. Compound\u2005<jats:bold>8<\/jats:bold> exhibited a rare 14,15,17\u2010<jats:italic>trinor<\/jats:italic>\u2010labdane skeleton. The structures of all these diterpenoids were elucidated by spectroscopic data analysis, electronic circular dichroism calculations, and single\u2010crystal X\u2010ray diffraction analysis. Compound <jats:bold>9<\/jats:bold> exhibited moderate anti\u2010inflammatory activity via the inhibition of NO production in lipopolysaccharide\u2010induced RAW 264.7\u2005cells.<\/jats:p>","DOI":"10.1002\/cbdv.202401089","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T02:14:51Z","timestamp":1715652891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Crotonoids A\u2013H, Labdane\u2010Type Diterpenoids with Anti\u2010Inflammatory Activity from <i>Croton Sublyratus<\/i>"],"prefix":"10.1002","volume":"21","author":[{"given":"Jing\u2010Jing","family":"Qi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  555 Zuchongzhi Road Shanghai 201203 People's Republic of China"},{"name":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  138 Xianlin Road Nanjing 210023 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  198 East Binhai Road Yantai Shandong 264117 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Yao","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  555 Zuchongzhi Road Shanghai 201203 People's Republic of China"},{"name":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  138 Xianlin Road Nanjing 210023 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun\u2010Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  555 Zuchongzhi Road Shanghai 201203 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4754-1616","authenticated-orcid":false,"given":"Jin\u2010Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  555 Zuchongzhi Road Shanghai 201203 People's Republic of China"},{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  198 East Binhai Road Yantai Shandong 264117 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4053-4870","authenticated-orcid":false,"given":"Jian\u2010Min","family":"Yue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  555 Zuchongzhi Road Shanghai 201203 People's Republic of China"},{"name":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  138 Xianlin Road Nanjing 210023 People's Republic of China"},{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  198 East Binhai Road Yantai Shandong 264117 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11515-011-1123-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.18433\/J3VW2F"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-020-04519-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152809787582534"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026033392462"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.07.019"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-50532007000100002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955711796575416"},{"key":"e_1_2_9_10_1","first-page":"63","volume":"5","author":"Rumki N.","year":"2013","journal-title":"C. 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