{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:04:53Z","timestamp":1771034693287,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two uncommon epoxyquinols, pyrrolocytosporin A (<jats:bold>1<\/jats:bold>) and cytosporin E<jats:sub>2<\/jats:sub> (<jats:bold>2<\/jats:bold>), along with the known cytosporin Y<jats:sub>1<\/jats:sub> (<jats:bold>3<\/jats:bold>), were isolated from the solid defined medium of the Arctic\u2010derived fungus <jats:italic>Eutypella<\/jats:italic> sp. D\u20101. Their structures were established through comprehensive analyses of spectroscopic and electronic circular dichroism data. Structurally, compound <jats:bold>1<\/jats:bold> represented the first nitrogen\u2010containing epoxyquinol characterized by a pyrrole fused cytosporin framework, while compound <jats:bold>2<\/jats:bold> contained an uncommon cyclic carbonate functionality. The antibacterial, immunosuppressive, anti\u2010inflammatory, and cytotoxic activities of all compounds were evaluated. Among the three metabolites, only compound <jats:bold>1<\/jats:bold> exhibited inhibitory effects on nitric oxide production induced by lipopolysaccharide with an IC<jats:sub>50<\/jats:sub> value of 6.55\u2005<jats:italic>\u03bc<\/jats:italic>M. Additionally, only compound <jats:bold>2<\/jats:bold> displayed inhibitory activity against ConA\u2010induced T\u2010cell proliferation with an IC<jats:sub>50<\/jats:sub> value of 9.85\u2005<jats:italic>\u03bc<\/jats:italic>M.<\/jats:p>","DOI":"10.1002\/cbdv.202401097","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T05:25:21Z","timestamp":1716009921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Uncommon Epoxyquinols Pyrrolocytosporin A and Cytosporin E<sub>2<\/sub> from the Fungus <i>Eutypella<\/i> sp. 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