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Nutritional profile was estimated, and major active compounds were isolated and identified. Biological evaluation of <jats:italic>L. shawii<\/jats:italic> extract on female rats was performed and measured by prolactin, follicular stimulating hormone, luteinizing hormone, estradiol, progesterone, tumor necrosis factor\u2010\u03b1, interleukin\u20106, heme oxygenase\u20101, nuclear respiratory factor\u20102, malondialdehyde, glutathione, DNA fragmentation, and ovarian architecture parameters. Data revealed the presence of <jats:italic>\u0264<\/jats:italic>\u2010tocopherol, vitamin C, magnesium, and 38 bioactive compounds in the fractions of <jats:italic>L. shawii<\/jats:italic>. Major constituents from gas chromatography\/mass spectrometry (GC\/MS) were 9, 12\u2010octadecadienoic acid (<jats:italic>Z<\/jats:italic>, <jats:italic>Z<\/jats:italic>), methyl ester, 2,7\u2010octadiene\u20101,6\u2010diol, and 2,6\u2010dimethyl hydroxy linalool but further five compounds (i.e., lupenone, betulin, lupeol acetate, stigmasterol, and \u03b2\u2010sitosterol\u2010<jats:sc>d<\/jats:sc>\u2010glucoside) were isolated and identified. Treatment of rats with the seeds extract post acrylamide administration ameliorated female sex hormones, oxidative stress, inflammation, DNA damage, and ovarian structure. In conclusion, <jats:italic>L. shawii<\/jats:italic> petroleum ether seeds fraction may be considered a nutraceutical agent for improving infertility disorders, oxidative stress, and inflammation due to its richness with biologically active phenolic and flavonoids compounds.<\/jats:p>","DOI":"10.1002\/cbdv.202401102","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T20:09:24Z","timestamp":1721074164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["GC\/MS Analysis and Compounds Isolation of <i>Lycium shawii<\/i> Petroleum Ether Seeds Extract for Regulating Nrf2\/OH\u20101 Pathway, Oxidative Stress, and Inflammation in Acrylamide\u2010Induced Infertility in Female Rats"],"prefix":"10.1002","volume":"22","author":[{"given":"Noha N.","family":"Nasr","sequence":"first","affiliation":[{"name":"Department of Therapeutic Chemistry National Research Centre Dokki, Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa M.","family":"Elbatanony","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department National Research Centre Dokki, Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3643-5842","authenticated-orcid":false,"given":"Manal A.","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Chemistry National Research Centre Dokki, Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933381"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.21101\/cejph.a6177"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjr.2015.05.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2016.48"},{"key":"e_1_2_11_6_1","first-page":"1092","article-title":"Acrylamide\u2010Induced Genotoxic, Biochemical and Pathological Perturbations in Malerats Liver","volume":"7","author":"Sabik L.","year":"2011","journal-title":"Journal of American Science"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-14722-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-2603"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/2221-1691.343390"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/916212"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043809"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/RAF-21-0038"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2011.11.014"},{"key":"e_1_2_11_14_1","first-page":"754","article-title":"SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS\u2010Dependent Manner via Regulation of the Nrf2\/HO\u20101 Pathway","volume":"9","author":"Sun M.","year":"2019","journal-title":"Frontiers"},{"issue":"10","key":"e_1_2_11_15_1","first-page":"977","article-title":"Protective Effect of Geraniolon Oxidative, Inflammatory and Apoptotic Alterations in Isoproterenol Induced Cardiotoxicity: Role of the Keap1 \/Nrf2\/HO\u20101 and PI3K\/Akt\/mTOR Pathways","volume":"9","author":"Younis B.","year":"2020","journal-title":"Anti\u2010Oxidants"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.33899\/ijvs.2022.133333.2207"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.31254\/phyto.2022.11301"},{"key":"e_1_2_11_18_1","first-page":"1099","article-title":"In Vitro Antiviral, Cytotoxic, Antioxidant and Hypolipidemic Activities of Polysaccharide Isolated From Marine Algae","volume":"7","author":"Matloub A. 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