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Although conventional modalities, like chemotherapy, have been applied for the inhibition of this cancer, they have not led to the suppression of lung cancer owing to their deficiencies. Thus, we developed a novel polylactic\u2010co\u2010glycolic acid (PLGA)\u2010polyamidoamine G4 (PAMAM G4)\u2010polycaprolactone (PCL) nanocarrier for efficient delivery of curcumin (Cur) to A549 lung cancer cells. The synthesized nanocarrier was characterized by applying analytical techniques, FT\u2010IR, DLS, TEM, and TGA. Successful synthesis, nano\u2010size diameter (40\u201380\u2005nm), near neutral surface charge (8.0\u2005mV), and high drug entrapment (11.5\u2009%) were measured for the nanocarrier. Controlled (about 5 folds within first 2\u2005h) and pH\u2010sensitive (2\u20133 folds faster within first hours) Cur release observed for PLGA\u2010PAMAM\u2010PCL\u2010Cur. Cell viability test (MTT assay) indicated the high capability of nanocarrier in suppression of A549 cancer cells (21\u2009% viability after 24\u2005h of treatment with 200\u2005nM) while did not result in toxicity on MSC normal cells. The IC\n                    <jats:sub>50<\/jats:sub>\n                    observed for 50\u2005nM at 24\u2005h of post\u2010treatment in A549 cells. The qRT\u2010PCR technique indicated inducing the expression of apoptotic genes (Caspase9 and Bax) by 6\u20138 folds and suppressing anti\u2010apoptotic gene (Bcl2) by 7 folds. ROS considerably increased in cancer cells as well. This nanocarrier would be a promising drug delivery system against lung cancer.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401106","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T13:45:55Z","timestamp":1721137555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Biocompatible PAMAM\u2010PLGA\u2010PCL Nanocarrier for Efficient Curcumin Delivery to Lung Cancer Cells: In Vitro Studies"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9632-0444","authenticated-orcid":false,"given":"Yasir","family":"Qasim Almajidi","sequence":"first","affiliation":[{"name":"Department of Pharmacy (pharmaceutics) Baghdad College of Medical Sciences  10047 Baghdad Iraq"},{"name":"Department of Pharmaceutics College of Pharmacy Al-Nahrain university  10072 Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4941-665X","authenticated-orcid":false,"given":"Ali Q.","family":"Jawad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Al-Nahrain university  10072 Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1158-4163","authenticated-orcid":false,"given":"Ahmed","family":"Abdulameer Albadri","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (pharmaceutics) Baghdad College of Medical Sciences  10047 Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c10892"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2020.102125"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114177"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.07.089"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2018.01.011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202000206"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2021.09.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2019.05.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2020.1748638"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119020"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101536"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1823"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","unstructured":"A.\u2005K.\u2005O. 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