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Steadily rising cases from the last few decades suggest the failure of currently available drugs in containment of this disease. \u03b1\u2010Glucosidase is a potential target for effectively tackling this disease and attracting significant interest from medicinal chemists around the globe. Besides having a set of side effects, currently available \u03b1\u2010glucosidase inhibitors (carbohydrate mimics) offer better tolerability, safety, and synergistic pharmacological outcomes with other antidiabetic drugs therefore medicinal chemists have working extensively over last three decades for developing alternative \u03b1\u2010glucosidase inhibitors. The 1,2,3\u2010Triazole nucleus is energetically used by various research groups around the globe for the development of \u03b1\u2010glucosidase inhibitors posing it as an optimum scaffold in the field of antidiabetic drug development. This review is a systematic analysis of \u03b1\u2010glucosidase inhibitors developed by employing 1,2,3\u2010triazole scaffold with special focus on design strategies, structure\u2010activity relationships, and mechanism of inhibitory effect. This article will act as lantern for medicinal chemists in developing of potent, safer, and effective \u03b1\u2010glucosidase inhibitors with desired properties and improved therapeutic efficacy.<\/jats:p>","DOI":"10.1002\/cbdv.202401109","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T04:35:32Z","timestamp":1719894932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Recent Developments in 1,2,3\u2010Triazole Based \u03b1\u2010Glucosidase Inhibitors: Design Strategies, Structure\u2010Activity Relationship and Mechanistic Insights"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-8032","authenticated-orcid":false,"given":"Atamjit","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University  Amritsar, Punjab 143005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karanvir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University  Amritsar, Punjab 143005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University  Amritsar, Punjab 143005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttam","family":"Kaur","sequence":"additional","affiliation":[{"name":"University School of Business Management Chandigarh University  Gharuan 140413 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamaljit","family":"Kaur","sequence":"additional","affiliation":[{"name":"Hershey Dental Group  Hershey, Pennsylvania 17033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preet","family":"Mohinder Singh Bedi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University  Amritsar, Punjab 143005 India"},{"name":"Drug and Pollution testing Laboratory Guru Nanak Dev University  Amritsar, Punjab 143005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2018.09.001"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.53730\/ijhs.v5n1.2864"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4599-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00061-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-016-4414-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40842-015-0001-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.04.027"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12992-019-0451-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2023.110823"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.13.03032"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-023-01501-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00025-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0046"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2001136"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb45030126"},{"key":"e_1_2_9_18_1","unstructured":"J.\u2005J. 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