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Their chemical structures were elucidated to be 11\u2010methoxysawaranospiroride C (<jats:bold>1<\/jats:bold>), 6<jats:italic>\u03b1<\/jats:italic>,9<jats:italic>S<\/jats:italic>,10,13\u2010tetrahydroxymegastigmane\u20103\u2010one (<jats:bold>2<\/jats:bold>), 11\u2010hydroxyaphanamixin B (<jats:bold>3<\/jats:bold>), (2<jats:italic>Z<\/jats:italic>,6<jats:italic>E<\/jats:italic>,13<jats:italic>E<\/jats:italic>)\u20102,6,13\u2010triene\u201011,15\u2010dihydroxyphytanic acid (<jats:bold>4<\/jats:bold>), cinnacasside D (<jats:bold>5<\/jats:bold>), cinnacasside E (<jats:bold>6<\/jats:bold>), vilsonol F (<jats:bold>7<\/jats:bold>), (3<jats:italic>S<\/jats:italic>,5<jats:italic>R<\/jats:italic>,6<jats:italic>S<\/jats:italic>,7<jats:italic>E<\/jats:italic>,9<jats:italic>R<\/jats:italic>)\u20103,5,6,9\u2010tetrahydroxy\u20107\u2010en\u2010megastigmane (<jats:bold>8<\/jats:bold>), (3<jats:italic>S<\/jats:italic>,5<jats:italic>R<\/jats:italic>,6<jats:italic>R<\/jats:italic>,7<jats:italic>E<\/jats:italic>,9<jats:italic>R<\/jats:italic>)\u20103,6,9,10\u2010tetrahydroxy\u20107\u2010en\u2010megastigmane (<jats:bold>9<\/jats:bold>), citroside A (<jats:bold>10<\/jats:bold>), <jats:italic>threo<\/jats:italic>\u20101\u2010(3,4,5\u2010trimethoxyphenyl)\u20101,2,3\u2010propanetriol (<jats:bold>11<\/jats:bold>), 3,4,5\u2010trimethoxyphenyl\u20101\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranoside (<jats:bold>12<\/jats:bold>), <jats:italic>p<\/jats:italic>\u2010coumaric acid (<jats:bold>13<\/jats:bold>), ferulic acid (<jats:bold>14<\/jats:bold>) by HR\u2010ESI\u2010MS, ECD, 1D\u2010, and 2D\u2010NMR spectra. Compounds <jats:bold>1<\/jats:bold>, <jats:bold>3<\/jats:bold>, <jats:bold>4<\/jats:bold>, and <jats:bold>9<\/jats:bold> showed NO production inhibitory activity in LPS activated RAW 264.7 cells with IC<jats:sub>50<\/jats:sub> values of 42.0, 67.9, 20.5, and 78.6\u2005\u03bcM, respectively, while the remaining compounds were inactive with IC<jats:sub>50<\/jats:sub> values over 100\u2005\u03bcM.<\/jats:p>","DOI":"10.1002\/cbdv.202401118","type":"journal-article","created":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T04:40:07Z","timestamp":1716612007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Four Unidentified Compounds Isolated from the Stem Barks of <i>Aphanamixis polystachya<\/i> and Their NO Production Inhibition in LPS Activated RAW 264.7 Cells"],"prefix":"10.1002","volume":"21","author":[{"given":"Ngo","family":"Anh Bang","sequence":"first","affiliation":[{"name":"Institute of Marine Biochemistry  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"},{"name":"Graduate University of Science and Technology  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Thi Thuy Hang","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong","family":"Thi Hai Yen","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Huy Hoang","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong","family":"Thi Dung","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"The Cuong","sequence":"additional","affiliation":[{"name":"Institute of Ecology and Biological Resources  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham","family":"Hai Yen","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Xuan Nhiem","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"},{"name":"Graduate University of Science and Technology  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bui","family":"Huu Tai","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"},{"name":"Graduate University of Science and Technology  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-6990","authenticated-orcid":false,"given":"Phan","family":"Van Kiem","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"},{"name":"Graduate University of Science and Technology  VAST, 18 Hoang Quoc Viet, Cau Giay Hanoi 10072 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"e_1_2_11_1_1","unstructured":"S.\u2005K. 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