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Additionally, molecular docking studies were performed to investigate the binding characteristics of compounds <jats:bold>4a<\/jats:bold> and <jats:bold>5c<\/jats:bold> with fungal lanosterol 14\u03b1\u2010demethylase and human topoisomerase I\u2013II, respectively, thereby contributing to the elucidation of their <jats:italic>in\u2005vitro<\/jats:italic> antifungal and cytotoxic properties. Furthermore, compounds <jats:bold>4a<\/jats:bold> and <jats:bold>5c<\/jats:bold>, via SwissADME prediction, could exhibit favorable physicochemical and pharmacokinetic properties. In conclusion, this study provides valuable insights into the potential of quinolin\u20102\u2010one hydrazones as promising candidates for the development of novel antimicrobial and anticancer agents in the future.<\/jats:p>","DOI":"10.1002\/cbdv.202401142","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T07:19:08Z","timestamp":1721459948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis, Antimicrobial \u2010 Cytotoxic Evaluation, and Molecular Docking Studies of Quinolin\u20102\u2010one Hydrazones Containing Nitrophenyl or Isonicotinoyl\/Nicotinoyl Moiety"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-1884","authenticated-orcid":false,"given":"Nam Q. 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