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Forty rats were divided into four groups (i) non diabetic rats, (ii) non diabetic rats +10\u2009% AFS, (iii) diabetic rats, (iv) diabetic rats +10\u2009% AFS. Flame\u2010SAA analysis revealed a rich content in micro\u2010elements, HPLC DAD\u2010FLD analysis revealed twenty components with rutin and ferulic acid being the major compounds in AFS hydro\u2010methanolic extract while spectrophotometric assays scrutinized moderate contents in total phenolics and flavonoids. The extract was potent in scavenging ABTS\u22c5<jats:sup>+<\/jats:sup> and DPPH<jats:sup>+<\/jats:sup> (42.06\u00b12.14 and 55.84\u00b14.14\u2005mg TE\/g), reducing Fe<jats:sup>3+<\/jats:sup> and Mo<jats:sup>6+<\/jats:sup> (35.12\u00b12.45 and 29.89\u00b13.12\u2005mg TE\/g) and inhibiting AGEs (IC50=1.03\u00b10.02\u2005mg\/ml). <jats:italic>In vivo<\/jats:italic>, 10\u2009%AFS\u2010 supplemented diet (w\/w) was found to elicit a significant reduction in glycemia (66.74\u2009%), TNF \u03b1 (9.4\u2009%), IL\u20106 (23.74\u2009%), CRP (31.10\u2009%), liver enzymes, lipid peroxidation (MDA) (47.24\u2009%;30\u2009%), protein carbonyl (PCO) (28.35\u2009%; 27.15\u2009%), improvement in insulin level (79.74\u2009%), reduced glutathione amount (GSH) (41.01\u2009%; 16.55\u2009%), glutathione peroxidase (GPx) (45.80\u2009%; 56.37\u2009%), catalase (CAT) (24.44\u2009%; 35.42\u2009%) and glutathione\u2010S\u2010transferase (GST) (22.78\u2009%; 22.90\u2009%) activities, in liver and pancreas respectively, along with a rejuvenation of hepatic and pancreatic histological features. These outcomes disclosed that AFS is endowed with biologically effective components which could be decent applicant to attain the objective of mitigating glycation, oxidative stress and diabetes\u2010related complications.<\/jats:p>","DOI":"10.1002\/cbdv.202401183","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T17:34:29Z","timestamp":1726248869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phenolic Profiling, <i>In Vitro<\/i> Antiglycation, Antioxidant Activities, and Antidiabetic Effect of Algerian <i>Trigonella Foenum\u2010Graecum<\/i> L. in Rats Administered a <i>\u03b2<\/i>\u2010Cell Toxicant"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-6511","authenticated-orcid":false,"given":"Maram","family":"Hachouf","sequence":"first","affiliation":[{"name":"Applied Biochemistry and Microbiology Laboratory Department of biochemistry, Faculty of Sciences Badji Mokhtar University  BP 12, Sidi Amar, 23000 Annaba Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7941-1758","authenticated-orcid":false,"given":"Ouassila","family":"Aouacheri","sequence":"additional","affiliation":[{"name":"Animal Ecophysiology Laboratory Department of biology, Faculty of Sciences Badji Mokhtar University  BP 12, Sidi Amar, 23000 Annaba Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4251-7481","authenticated-orcid":false,"given":"Saad","family":"Saka","sequence":"additional","affiliation":[{"name":"Animal Ecophysiology Laboratory Department of biology, Faculty of Sciences Badji Mokhtar University  BP 12, Sidi Amar, 23000 Annaba Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adua","family":"Marzocchi","sequence":"additional","affiliation":[{"name":"ChimNutra labs Department of Pharmacy University of Naples \u201cFederico II\u201d  80131 Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0251-9936","authenticated-orcid":false,"given":"Gian","family":"Carlo Tenore","sequence":"additional","affiliation":[{"name":"ChimNutra labs Department of Pharmacy University of Naples \u201cFederico II\u201d  80131 Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05769-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2020.1826529"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.058"},{"key":"e_1_2_9_5_1","first-page":"542","volume":"12","author":"Khalid M.","year":"2022","journal-title":"Biomol. 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