{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:50Z","timestamp":1786977350073,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Herbal remedies have shown great promise for improving human health. The plant\n                    <jats:italic>Crotalaria quinquefolia<\/jats:italic>\n                    is used in folk medicine to cure different diseases, including scabies, fever, discomfort, and lung infections. The present research was designed to explore bioactive compounds and evaluate the neuropharmacological effects of\n                    <jats:italic>C. quinquefolia<\/jats:italic>\n                    extract through\n                    <jats:italic>in\u2005vivo<\/jats:italic>\n                    and\n                    <jats:italic>in silico<\/jats:italic>\n                    approaches. Different secondary metabolites as well as the antioxidant activity were measured. Furthermore, chemical compounds were identified by HPLC and GCMS analysis. The neuropharmacological activity was examined by hole cross, hole board, open field, Y\u2013maze, elevated plus maze, and thiopental sodium induced sleeping time tests in mice at doses of 100\u2005mg\/kg and 200\u2005mg\/kg b.w. (p.o). Besides, an\n                    <jats:italic>in\u2010silico<\/jats:italic>\n                    study was performed on proteins related to Alzheimer disease. The extract showed a significant content of secondary metabolites and antioxidant potential. The\n                    <jats:italic>in\u2010silico<\/jats:italic>\n                    analysis showed that myricetin, quercetin, rutin, and kaempferol have good binding affinity with studied proteins, and QSAR studies revealed potential benefits for treating dementia, and age\u2010related macular degeneration. The findings of the present neurological activity collectively imply that the extract has strong CNS depressant and anxiolytic activity. Therefore,\n                    <jats:italic>C. quinquefolia<\/jats:italic>\n                    can be a potential source of compounds to treat Alzheimer disease.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401257","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T14:15:11Z","timestamp":1726496111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Crotalaria quinquefolia<\/i>\n                    L. Revealed as a Potential Source of Neuropharmacophore in Both Experimental and Computational Studies"],"prefix":"10.1002","volume":"22","author":[{"given":"Md. Nazmul","family":"Hasan Zilani","sequence":"first","affiliation":[{"name":"Department of Pharmacy Jashore University of Science and Technology  Jashore 7408 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazmun","family":"Nahar","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic Engineering and Biotechnology Jashore University of Science and Technology  Jashore 7408 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamika","family":"Shome","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Jashore University of Science and Technology  Jashore 7408 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Mohaimenul Islam","family":"Tareq","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic Engineering and Biotechnology Jashore University of Science and Technology  Jashore 7408 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha","family":"Biswas","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic Engineering and Biotechnology Jashore University of Science and Technology  Jashore 7408 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabana","family":"Bibi","sequence":"additional","affiliation":[{"name":"Department of Biosciences Shifa Tameer-e-Millat University  Islamabad 41000 Pakistan"},{"name":"Department of Health Sciences Novel Global Community Educational Foundation  Hebersham, NSW 2770 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy King Saud University, Post Box 2455  Riyadh 11451 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norah A.","family":"Albekairi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy King Saud University, Post Box 2455  Riyadh 11451 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosam M.","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Directorate of Medical Service Ministry of Interior  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Nazmul","family":"Hasan","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic Engineering and Biotechnology Jashore University of Science and Technology  Jashore 7408 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1777774"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00465-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c05609"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00486"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01484-7"},{"key":"e_1_2_11_6_1","volume":"14","author":"Reiss A. 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