{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:11:26Z","timestamp":1790028686402,"version":"4.0.1"},"reference-count":79,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Water hyacinth (\n                    <jats:italic>Eichhornia crassipes<\/jats:italic>\n                    (Mart.) Solms) is a highly invasive aquatic weed native to the Amazonia basin, known for its rapid propagation, adaptability, and utilization in traditional medicine. The study aims to unveil the therapeutic potential of water hyacinth flowers methanolic extract (EC CME) and its four kupchan fractions (EC PESF, EC DCMSF, EC EASF, EC ASF) through diversified chemical\u2010pharmacological approaches. GC\u2010MS\/MS of EC\u2010CME uncovered a rich tapestry of 72 phytochemical components.\n                    <jats:italic>In vitro<\/jats:italic>\n                    DPPH scavenging assay and total phenolic content determination assay deciphered promising antioxidant assays with remarkably low IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.353 and 0.485\u2005\u03bcg\/mL, respectively for EC\u2010ESF and EC\u2010ASF. Besides, different\n                    <jats:italic>in\u2005vivo<\/jats:italic>\n                    tests, including tail emersion, acetic acid\u2010induced writhing, and thiopental\u2010induced sleeping test of EC\u2010CME, yielded a remarkable 8.61\u00b10.29\u2005min of tail immersion time compared to the control's 2.05\u00b10.11\u2005min at the highest dose (600\u2005mg\/kg). The best % inhibition of writhing was recorded as 47.96\u2009% accrued in 400\u2005mg\/kg dose, indicating robust pain\u2010relieving properties. The onset and duration of sleep are significantly ameliorated for EC\u2010CME, unveiling its antidepressant potential. Besides, molecular docking studies along with ADME\/T analysis also validated the wet lab findings as well as their safety, efficacy, and drug\u2010likeliness profile. Finally, this work can be an essential hint for utilizing aquatic weeds in drug development research.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401268","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T05:26:47Z","timestamp":1724390807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Unveiling the Therapeutic Potentials of Water Hyacinth (\n                    <i>Eichhornia crassipes<\/i>\n                    (Mart.) Solms) Flower against Oxidative Stress, Inflammation and Depressive Disorders: GC\u2010MS\/MS,\n                    <i>In Vitro, In Vivo<\/i>\n                    and\n                    <i>In Silico<\/i>\n                    Approaches"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5319-1398","authenticated-orcid":false,"given":"Hasin","family":"Hasnat","sequence":"first","affiliation":[{"name":"Department of Pharmacy School of Pharmaceutical Sciences State University of Bangladesh  Dhaka 1205 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima Jahan","family":"Riti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy School of Pharmaceutical Sciences State University of Bangladesh  Dhaka 1205 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1930-7890","authenticated-orcid":false,"given":"Suriya Akter","family":"Shompa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy School of Pharmaceutical Sciences State University of Bangladesh  Dhaka 1205 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-2278","authenticated-orcid":false,"given":"Safaet","family":"Alam","sequence":"additional","affiliation":[{"name":"Chemical Research Division Bangladesh Council of Scientific and Industrial Research  Dhaka 1205 Bangladesh"},{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy University of Dhaka  Dhaka 1000 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Mirazul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy School of Pharmaceutical Sciences State University of Bangladesh  Dhaka 1205 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdousy","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Pharmacy School of Pharmaceutical Sciences State University of Bangladesh  Dhaka 1205 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Salim","family":"Khan","sequence":"additional","affiliation":[{"name":"BCSIR Laboratories Rajshahi Bangladesh Council of Scientific and Industrial Research  Rajshahi 6206 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuxiao","family":"Shao","sequence":"additional","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University  Lishui People's Hospital, Lishui, Zhejiang 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlai","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Lishui Hospital of Wenzhou Medical University  Lishui People's Hospital, Lishui City, Zhejiang 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanghu","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University  Lishui People's Hospital, Lishui, Zhejiang 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9714-7660","authenticated-orcid":false,"given":"Peiwu","family":"Geng","sequence":"additional","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University  Lishui People's Hospital, Lishui, Zhejiang 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-3925","authenticated-orcid":false,"given":"Abdullah","family":"Al Mamun","sequence":"additional","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University  Lishui People's Hospital, Lishui, Zhejiang 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.3329\/bpj.v26i2.67807"},{"key":"e_1_2_11_2_1","first-page":"1003","volume":"12","author":"Taher M. A.","year":"2023","journal-title":"Chin. J. Anal. Chem."},{"key":"e_1_2_11_3_1","first-page":"1","volume":"22","author":"Emon N. U.","year":"2020","journal-title":"Adv. Tradit. Med."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5455\/jabet.2020.d127"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3329\/bpj.v24i2.54716"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3329\/bpj.v25i1.57837"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2016.05.001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3329\/bpj.v26i2.67808"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27533"},{"issue":"1","key":"e_1_2_11_10_1","first-page":"26","volume":"9","author":"Anuja S.","year":"2016","journal-title":"J. Environ. Sci. Technol."},{"key":"e_1_2_11_11_1","unstructured":"M.\u2005H. Julien Aciar Proc ACIAR 2000 5 pp. 8\u201320."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3391\/ai.2008.3.1.8"},{"issue":"6","key":"e_1_2_11_13_1","first-page":"94","volume":"8","author":"Degaga A. H.","year":"2018","journal-title":"J. Life Sci. Biomed."},{"key":"e_1_2_11_14_1","first-page":"205","volume":"2","author":"Dymond E. A.","year":"2002","journal-title":"J. Aquat. Work"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4018\/978-1-4666-9559-7.ch015"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2014.09.006"},{"issue":"2","key":"e_1_2_11_17_1","first-page":"2059","volume":"20","author":"Sharma A. K.","year":"2020","journal-title":"Plant Arch."},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3452172"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-83582017350100026"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3329\/bjm.v35i1.39797"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.842511"},{"issue":"3","key":"e_1_2_11_22_1","first-page":"209","volume":"1","author":"Dineshkumar G.","year":"2013","journal-title":"Int. J. Pure Appl. Zool."},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-397"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijcpr.2017.v9i3.19970"},{"issue":"2","key":"e_1_2_11_25_1","first-page":"494","volume":"10","author":"Jain C.","year":"2019","journal-title":"Int. J. Pharm. Sci. Res."},{"issue":"4","key":"e_1_2_11_26_1","first-page":"3266","volume":"24","author":"Elshafie H. S.","year":"2023","journal-title":"A Comprehensive Review on the Biological, Agricultural and Pharmaceutical Properties of Secondary Metabolites Based-Plant Origin"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijpb13010003"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(83)80023-5"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoleng.2012.03.002"},{"key":"e_1_2_11_30_1","first-page":"29","volume":"6","author":"Lalitha P.","year":"2014","journal-title":"Int. J. Pharmtech. Res."},{"key":"e_1_2_11_31_1","first-page":"207","volume":"31","author":"Virabalin R.","year":"1993","journal-title":"J. Aquat. Plant Manage."},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-017-2941-z"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nimb.2008.10.021"},{"issue":"1","key":"e_1_2_11_34_1","first-page":"81","volume":"9","author":"Al-Rubaye A. F.","year":"2017","journal-title":"Int. J. Toxicol. Pharmacol. Res."},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2101042"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104010"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2019.11.025"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X11666131120232135"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.18231\/j.joapr.2020.v.8.i.3.55.59"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00054a013"},{"issue":"2","key":"e_1_2_11_41_1","first-page":"90","volume":"5","author":"Sermakkani M.","year":"2012","journal-title":"Asian J. Pharm. Clin Res."},{"issue":"4","key":"e_1_2_11_42_1","first-page":"250","volume":"14","author":"Choi H. Y.","year":"2000","journal-title":"Phyther. Res. Int. J. Devoted Pharmacol. Toxicol. Eval. Nat. Prod. Deriv."},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2621.2002.00552.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-03162-5"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.nsa04bs42"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2020.11.004"},{"issue":"3","key":"e_1_2_11_48_1","first-page":"181","volume":"4","author":"Noor M. A. A.","year":"2015","journal-title":"J. Pharmacogn. Phytochem."},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/245431"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3329\/bpj.v26i2.67807"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92176-1"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1347069"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-25"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-005-1484-z"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJMR2019.9120"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9960-8"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(85)90086-4"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c07916"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/md18030138"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2008-5-604"},{"issue":"9","key":"e_1_2_11_61_1","first-page":"2259","volume":"2","author":"Kaur N.","year":"2011","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1284068"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.07.055"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40816-019-0148-5"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1359815"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11756-022-01057-z"},{"issue":"5","key":"e_1_2_11_67_1","first-page":"8","volume":"8","author":"Uppala P. K.","year":"2015","journal-title":"Asian J Pharm and Clinical Research"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135558"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880201003629323"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.01.044"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.05.043"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e28460"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-011-1163-0"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444903029718"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz424"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e08475"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.951933"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-018-0507-1"},{"issue":"9","key":"e_1_2_11_79_1","first-page":"232","volume":"13","author":"Rahman J.","year":"2020","journal-title":"Compd. Pharm."}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202401268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202401268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202401268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:12:26Z","timestamp":1773227546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202401268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,4]]},"references-count":79,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/cbdv.202401268"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202401268","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,4]]},"assertion":[{"value":"2024-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202401268"}}