{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:11:27Z","timestamp":1787163087312,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Indole\u20103\u2010carbaldehyde based novel ligand (E)\u20102\u2010((1\u2010benzyl\u20101H\u2010indol\u20103\u2010yl)methylene)\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methylhydrazine\u20101\u2010carbothioamide (\n                    <jats:bold>MBIHC<\/jats:bold>\n                    ) and its metal complexes [(MBIHC)\n                    <jats:sub>2<\/jats:sub>\n                    FeCl\n                    <jats:sub>2<\/jats:sub>\n                    ]Cl(\n                    <jats:bold>C1<\/jats:bold>\n                    ), [(MBIHC\n                    <jats:sup>\u2212<\/jats:sup>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    Co] (\n                    <jats:bold>C2<\/jats:bold>\n                    ), [(MBIHC\n                    <jats:sup>\u2212<\/jats:sup>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    Ni] (\n                    <jats:bold>C3<\/jats:bold>\n                    ), and [(MBIHC\n                    <jats:sup>\u2212<\/jats:sup>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    Cu] (\n                    <jats:bold>C4<\/jats:bold>\n                    ) have been synthesized. All synthesized compounds have been characterized by various spectroanalytical techniques. The structure of\n                    <jats:bold>MBIHC<\/jats:bold>\n                    was confirmed by single\u2010crystal X\u2010ray data. The geometry of metal complexes was determined by spectroscopic and computational studies. In the case of iron complex, ligand\n                    <jats:bold>MBIHC<\/jats:bold>\n                    coordinated to the metal ion in bidentate mode (\n                    <jats:italic>via<\/jats:italic>\n                    nitrogen, sulphur donor atoms) while in the case of cobalt, nickel, and copper complexes ligand act as a tridentate ligand (\n                    <jats:italic>via<\/jats:italic>\n                    nitrogen, sulphur, carbene donor atoms).\n                    <jats:italic>In vitro<\/jats:italic>\n                    , antifungal and antibacterial studies of ligand and metal complexes were assayed against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    ,\n                    <jats:italic>C. glabrata, E. coli<\/jats:italic>\n                    , and\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    pathogens. In antifungal activity, complex\n                    <jats:bold>C1<\/jats:bold>\n                    exhibited a greater inhibition zone than the other compounds for the both examined fungi\n                    <jats:italic>C. albicans<\/jats:italic>\n                    (24\u00b10.32\u2005mm) and\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    (20\u00b10.16\u2005mm). However, the antifungal activities of complex\n                    <jats:bold>C2<\/jats:bold>\n                    has shown better activity against both\n                    <jats:italic>E. coli<\/jats:italic>\n                    (25\u00b10.24\u2005mm) and\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    (16\u00b10.80\u2005mm) pathogens than the other examined compound. Complex\n                    <jats:bold>C2<\/jats:bold>\n                    has found even better than the benchmark drug Ampiciline in case of\n                    <jats:italic>E. coli<\/jats:italic>\n                    . Further, the DFT calculations and molecular docking studies also validate the experimental bioactivity results of examined compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401301","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T02:29:40Z","timestamp":1725589780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis, DFT, Molecular Docking, and Antimicrobial Studies of New Indole\u2010Thiosemicarbazone Ligand and Their Complexes with Fe(III), Co(II), Ni(II), Cu(II)"],"prefix":"10.1002","volume":"21","author":[{"given":"Jugmendra","family":"Singh","sequence":"first","affiliation":[{"name":"Catalysis and bio-inorganic research laboratory Department of Chemistry, Deshbandhu College University of Delhi  Kalkaji, New Delhi 110019 India"},{"name":"Department of Chemistry University of Delhi  New Delhi 110007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Gautam","sequence":"additional","affiliation":[{"name":"Catalysis and bio-inorganic research laboratory Department of Chemistry, Deshbandhu College University of Delhi  Kalkaji, New Delhi 110019 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhur B.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Atma Ram Sanatan Dharma College University of Delhi  New Delhi 110021 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Atma Ram Sanatan Dharma College University of Delhi  New Delhi 110021 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4732-5756","authenticated-orcid":false,"given":"Umesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Catalysis and bio-inorganic research laboratory Department of Chemistry, Deshbandhu College University of Delhi  Kalkaji, New Delhi 110019 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.133632"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.07.004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.07.019"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.02.043"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2022.04.814"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2018-0010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.08.013"},{"key":"e_1_2_10_8_1","first-page":"1","volume":"5815","author":"Devi J.","year":"2020","journal-title":"Appl. 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