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A major challenge is finding suitable natural plant resources for the development of functional ingredients. <jats:italic>Leptospermum<\/jats:italic>, a genus of the myrtle family (<jats:italic>Myrtaceae<\/jats:italic>), is primarily native to Australia. This genus has been traditionally used for the treatment of a range of ailments, such as colds, fever, constipation, diarrhoea, skin, inflammation, stomach disorder and both internal and external pain. Manuka honey, known for its medicinal properties, is produced from the nectar of <jats:italic>Leptospermum<\/jats:italic> flowers, and the leaves of some species are used for essential oil production. Various volatiles, such as pinene, citral and citronellal, have been identified in <jats:italic>Leptospermum<\/jats:italic> essential oils. In addition, various non\u2010volatile compounds like leptosperin, cyanidin, quercetin, ellagic acid, delphinidin and myricetin have been isolated from <jats:italic>Leptospermum<\/jats:italic> extracts. Preliminary studies have linked <jats:italic>Leptospermum<\/jats:italic> essential oils and extracts with various health\u2010promoting properties, such as antimicrobial activity, antidiabetes, anticancer and anti\u2010Alzheimer's disease activities, revealing potential applications of <jats:italic>Leptospermum<\/jats:italic> as functional ingredients. To provide a comprehensive understanding of <jats:italic>Leptospermum<\/jats:italic> for future research and applications, this review presents an overview of its botanical features, outlines volatile and non\u2010volatile active molecules identified in the genus, reviews potential health benefits and finally proposes trends for future studies on <jats:italic>Leptospermum<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cbdv.202401335","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T05:55:35Z","timestamp":1732686935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Comprehensive Review of the Botany, Bioactive Compounds and Health Benefits of <i>Leptospermum<\/i>"],"prefix":"10.1002","volume":"22","author":[{"given":"Phuong Lan","family":"Hoang","sequence":"first","affiliation":[{"name":"School of Environmental and Life Sciences College of Engineering, Science and Environment, The University of Newcastle  Ourimbah New South Wales Australia"},{"name":"Faculty of Food Science and Technology Vietnam National University of Agriculture  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6117-4974","authenticated-orcid":false,"given":"Quan","family":"Van Vuong","sequence":"additional","affiliation":[{"name":"School of Environmental and Life Sciences College of Engineering, Science and Environment, The University of Newcastle  Ourimbah New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7751\/telopea19894902"},{"key":"e_1_2_10_3_1","unstructured":"S.Williams (PhD thesis University of the Sunshine Coast Australia 2019)."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02906757"},{"key":"e_1_2_10_5_1","unstructured":"A. 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