{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:47:08Z","timestamp":1789670828551,"version":"4.0.1"},"reference-count":70,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Olive mill wastewater (OMWW), a byproduct of olive oil extraction, constitutes a natural resource of phenolic compounds. Hydroxytyrosol (HT), the predominant compound, was reported to have antioxidant, anti\u2010inflammatory, and neuroprotective effects. This research aims to evaluate the effect of OMWW bioproduct rich in HT on retinal glial function, glutamate metabolism, and synaptic transmission alterations mediated by hyperglycemia and dyslipidemia in high\u2010calorie diet (HCD)\u2010induced diabetic retinopathy (DR) in\n                    <jats:italic>Psammomys obesus<\/jats:italic>\n                    . Animals were divided into four groups. Two diabetic animal groups (D) received an HCD, one untreated (D) and another receiving HT\u2010OMWW treatment (20\u00a0mg\/kg body weight: bw) (D+); the two other groups were used as controls (C and C+). During 7 months, food and water intake, body weight, glycemia, hematocrit, and serum lipid parameters were assessed. At 3, 5, and advanced 7 months of DR, immunohistochemical studies were performed to identify key proteins implicated in the protection of DR. HT\u2010OMWW has anti\u2010obesity, hypoglycemic, and hypolipidemic effects. Its long\u2010term administration attenuates retinal glial reactivity, microglia number, changes in glutamate homeostasis, and synaptic function in diabetic animals with retinopathy. These results suggest that HT\u2010OMWW extract seems to have promising in vivo anti\u2010diabetic, anti\u2010dyslipidemic, and neuroprotective effects in\n                    <jats:italic>P. obesus<\/jats:italic>\n                    , a model of DR\u2010like humans.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401351","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T22:13:31Z","timestamp":1735856011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hydroxytyrosol\u2010Rich Olive Mill Wastewater, a Potential Protector Against Dyslipidemia, Diabetes, and Diabetic Retinopathy in\n                    <i>Psammomys obesus<\/i>"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1702-6384","authenticated-orcid":false,"given":"Oumaima","family":"Achour","sequence":"first","affiliation":[{"name":"Laboratory of Physiopathology, Food and Biomolecules (PAB) of the High Institute of Biotechnology, Sidi Thabet (ISBST), Univ Manouba (UMA) BiotechPole Sidi Thabet  Sidi Thabet Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2956-3651","authenticated-orcid":false,"given":"Yosr Z.","family":"Haffani","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopathology, Food and Biomolecules (PAB) of the High Institute of Biotechnology, Sidi Thabet (ISBST), Univ Manouba (UMA) BiotechPole Sidi Thabet  Sidi Thabet Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8899-0859","authenticated-orcid":false,"given":"Sihem","family":"Mbarek","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopathology, Food and Biomolecules (PAB) of the High Institute of Biotechnology, Sidi Thabet (ISBST), Univ Manouba (UMA) BiotechPole Sidi Thabet  Sidi Thabet Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0802-9679","authenticated-orcid":false,"given":"Oumayma","family":"Hammami","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopathology, Food and Biomolecules (PAB) of the High Institute of Biotechnology, Sidi Thabet (ISBST), Univ Manouba (UMA) BiotechPole Sidi Thabet  Sidi Thabet Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1585-4052","authenticated-orcid":false,"given":"Monssef","family":"Feki","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Biochemistry, Rabta Hospital, LR99ES11, Faculty of Medicine of Tunis University of Tunis El Manar, La Rabta  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4468-9683","authenticated-orcid":false,"given":"Ayachi","family":"Zemmel","sequence":"additional","affiliation":[{"name":"Herbes de Tunisie, El Mansoura Kesra  Siliana Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-5145","authenticated-orcid":false,"given":"Serge","family":"Picaud","sequence":"additional","affiliation":[{"name":"INSERM, CNRS, Institut de la Vision Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9862-9744","authenticated-orcid":false,"given":"Nourh\u00e8ne","family":"Boudhrioua","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopathology, Food and Biomolecules (PAB) of the High Institute of Biotechnology, Sidi Thabet (ISBST), Univ Manouba (UMA) BiotechPole Sidi Thabet  Sidi Thabet Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5235-8504","authenticated-orcid":false,"given":"Rafika Ben","family":"Chaouacha\u2010Chekir","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopathology, Food and Biomolecules (PAB) of the High Institute of Biotechnology, Sidi Thabet (ISBST), Univ Manouba (UMA) BiotechPole Sidi Thabet  Sidi Thabet Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110708"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261249"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25114"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.TR120000981"},{"key":"e_1_2_10_6_1","first-page":"346","article-title":"Association of Serum Lipid Levels With Diabetic Retinopathy","volume":"6","author":"Cetin E. 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