{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:07:44Z","timestamp":1791925664365,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this work, the volatile components of <jats:italic>Erigeron sublyratus<\/jats:italic> essential oils and their anti\u2010inflammatory and cytotoxic activities were investigated for the first time. Gas chromatography\u2010mass spectrometry (GC\u2010MS) analysis identified 28 components in the root and aerial part essential oils. The main components included <jats:italic>cis<\/jats:italic>\u2010lachnophyllum ester (53.4\u201364.2\u2009%), germacrene D (5.6\u20138.6\u2009%), <jats:italic>trans<\/jats:italic>\u2010\u03b2\u2010ocimene (2.6\u20137.5\u2009%), <jats:italic>\u03b2<\/jats:italic>\u2010caryophyllene (4.7\u20136.8\u2009%), <jats:italic>\u03b2<\/jats:italic>\u2010myrcene (2.0\u20136.3\u2009%), and (<jats:italic>E<\/jats:italic>)\u2010<jats:italic>\u03b2<\/jats:italic>\u2010farnesene (4.8\u20135.0\u2009%). The aerial part essential oil inhibited nitric oxide (NO) production on LPS\u2010induced RAW 264.7 cells, with an IC<jats:sub>50<\/jats:sub> value of 1.41\u00b10.10\u2005\u03bcg\/mL. In addition, both root and aerial part essential oils exhibited cytotoxic activity against MCF\u20107, SK\u2010LU\u20101, and HepG2. Molecular docking simulation results revealed that (<jats:italic>E<\/jats:italic>)\u2010<jats:italic>\u03b2<\/jats:italic>\u2010farnesene strongly binds to the VEGFR\u20102 enzyme, while <jats:italic>\u03b4<\/jats:italic>\u2010cadinene has a high affinity to the COX\u20102 enzyme <jats:italic>via<\/jats:italic> hydrophobic interactions. These findings proposed that <jats:italic>E. sublyratus<\/jats:italic> essential oils can be exploited for their anti\u2010inflammatory and anti\u2010cytotoxicity potential.<\/jats:p>","DOI":"10.1002\/cbdv.202401356","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T02:40:46Z","timestamp":1727664046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Chemical Constituents, Biological Activities and Molecular Docking Studies of Root and Aerial Part Essential Oils from <i>Erigeron sublyratus<\/i> Roxb. ex DC. 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