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Alkyl <jats:sc>d<\/jats:sc>\u2010glucosides and <jats:sc>d<\/jats:sc>\u2010galactosides showed mainly similar antiproliferative properties on leukemia cell lines, while <jats:italic>N<\/jats:italic>\u2010acetyl <jats:sc>d<\/jats:sc>\u2010glucosaminides revealed diverse properties with lower efficacy. Also, the cytokine response of RAW 264.7 macrophages was significantly influenced by the type of sugar moiety and (thio)alkyl chain length. Contrary to the proliferation results, <jats:sc>d<\/jats:sc>\u2010glucosides and <jats:sc>d<\/jats:sc>\u2010galactosides did not reveal so evident similarities in induction of cytokines. The <jats:italic>C. albicans<\/jats:italic> biofilm treatment with the (thio)alkyl glycosides resulted in a significant reduction of <jats:italic>Candida<\/jats:italic> cell proliferation resembling the structure and concentration differences of glycosides. The activity of tested derivatives (GalOC12 &gt; GlcOC12 \u2248 ManOC12 &gt; GlcNAcOC12) against the <jats:italic>C. albicans<\/jats:italic> azole\u2010sensitive clinical strain biofilm differ from the efficacy against <jats:italic>C. albicans<\/jats:italic> multiazole\u2010resistant clinical strain biofilm (GlcOC12 &gt; ManOC12 \u2248 GalOC12 &gt; GlcNAcOC12). The obtained data clearly demonstrated that the structure of saccharide unit caused different bioimmunological behaviour of such glycosides regardless of the same aglycone length.<\/jats:p>","DOI":"10.1002\/cbdv.202401368","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T12:06:45Z","timestamp":1727438805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>In Vitro<\/i> Assessment of Immunobiological Effectivity of Synthetic Non\u2010Ionic Glycolipids"],"prefix":"10.1002","volume":"22","author":[{"given":"Ema","family":"Paulovi\u010dov\u00e1","sequence":"first","affiliation":[{"name":"Dept. 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