{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:30:17Z","timestamp":1777894217110,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018551","name":"Science and Technology Innovation Talents in Universities of Henan Province","doi-asserted-by":"publisher","award":["2021YFE0110700"],"award-info":[{"award-number":["2021YFE0110700"]}],"id":[{"id":"10.13039\/501100018551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aims to explore the feasibility of using network pharmacology and molecular docking technology to predict the effects of active components from oil tree peony seed meal (PSM) on swine diseases. Ten active components of PSM were screened Screening through literature search and network pharmacology standards, including Betulinic acid, Quercetin, Kaempferol, Luteolin, Isorhamnetin, Hydroxygenkwanin, Hederagenin, Benzoyl Paeoniflorin, Albiflorin, Paeoniflorin. Ten types of swine diseases were selected, including African Swine Fever, Aftosa, Swine Vesicular Disease, Transmissible Gastroenteritis, Swine Streptococcal Infection, Blue Aural Disease, Swine Infectious Atrophic Rhinitis, Swine Influenza, Swine Erysipelas, Swine Epidemic Encephalitis. The results showed that the average number of cross genes between the potential target genes of PSM active components and each swine disease target gene accounted for 7.64\u2009% of the total number of swine disease target genes. The GO enrichment analyses showed that putative targets exist in endosomes, lysosomes, cell membranes, nerves, growth factor activity, receptor tyrosine kinase binding, enzyme binding, growth factor binding, transcription coactivator binding, oxidoreductase activity, prostaglandin E receptor activity and insulin receptor substrate binding. The KEGG enrichment analysis results showed that these putative genes were involved in various cancer progression pathways, signaling pathways, and hormone regulatory pathways. A total of 8 core targets were obtained through protein\u2010protein interaction networks analysis, including Protein Kinase CAMP\u2010Activated Catalytic Subunit Alpha (PRKACA), Non\u2010Receptor Tyrosine Kinase (SRC), Mitogen\u2010Activated Protein Kinase 1 (MAPK1), E1A Binding Protein P300 (EP300), Hypoxia Inducible Factor 1 Subunit Alpha (HIF1A), Phosphatidylinositol\u20104,5\u2010Bisphosphate 3\u2010Kinase Catalytic Subunit Beta (PIK3CB), C\u2010X\u2010C chemokine receptor type 4 (CXCR4) and Estrogen Receptor 2 (ESR2). The HIF\u20101 signaling pathway was found to be associated with all 10 selected swine diseases. The PD\u2010L1 expression, and PD\u20101 checkpoint pathway in cancer, and thyroid hormone signaling pathway were not only enriches the core target with a quantity of 7, but also associated with 9 Swine diseases. In addition, the molecular docking results indicate that the core ingredients have strong affinity with hub genes. The research suggests that the active components of PSM may intervene in swine diseases through multiple components, targets, and pathways.<\/jats:p>","DOI":"10.1002\/cbdv.202401384","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T17:34:11Z","timestamp":1724348051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Effect of Active Components in Oil Tree Peony Seed Meal on Swine Disease Resistance and its Potential Mechanisms Based on Network Pharmacology and Molecular Docking"],"prefix":"10.1002","volume":"21","author":[{"given":"Xu","family":"Yang","sequence":"first","affiliation":[{"name":"Henan University of Science and Technology  471023 Luoyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Xue","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology  471023 Luoyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinglong","family":"He","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology  471023 Luoyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Song","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology  471023 Luoyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Guo","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology  471023 Luoyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0126-2080","authenticated-orcid":false,"given":"Xiaogai","family":"Hou","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology  471023 Luoyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503141112"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2014.05.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.115539"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00424-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.101696"},{"issue":"12","key":"e_1_2_8_6_1","first-page":"3745","volume":"54","author":"Li H. 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