{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:09:43Z","timestamp":1773281383513,"version":"3.50.1"},"reference-count":74,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Justicia vahlii<\/jats:italic>\n                    Roth. is an important wild medicinal food plant traditionally used for treating inflammation and various common ailments. This study investigated the chemical composition, antioxidant, enzyme inhibition and toxicity profiles of\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexane (\n                    <jats:italic>n<\/jats:italic>\n                    HEJv) and chloroform (CEJv) extracts of\n                    <jats:italic>J. vahlii<\/jats:italic>\n                    . Moreover, the effect of the extracts was evaluated on CCl\n                    <jats:sub>4<\/jats:sub>\n                    induced liver injury. The total phenolic and flavonoid contents were present in both extracts in significant amount. The UPLC\u2212Q\u2010TOF\u2010MS and GC\u2010MS profiling of CEJv tentatively identified several important phytocompounds. The CEJv extract was comparatively more active for antioxidant activity and\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010amylase inhibition, whereas the\n                    <jats:italic>n<\/jats:italic>\n                    HEJv extract presented higher inhibition potential against urease, tyrosinase, and\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase enzymes. Similarly, the\n                    <jats:italic>in\u2010silico<\/jats:italic>\n                    study of four major compounds, i.\u2009e., 1\u2010acetoxypinoresinol, 3\u2010hydroxysebacic acid, nortrachelogenin, and viscidulin\u2010III have shown a good docking score against the clinically significant enzymes. The acute oral toxicity and brine shrimp lethality assaysrevealed the extracts as non\u2010toxic. The CCl\n                    <jats:sub>4<\/jats:sub>\n                    treated animals showed a geared depletion of various antioxidant enzymes which were significantly reversed with the treatment of the extracts. Overall, the study's findings revealed\n                    <jats:italic>J. vahlii<\/jats:italic>\n                    with antioxidant mediated hepatoprotective and enzyme inhibition potential and warrant further research on isolation of the bioactive compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401432","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T15:43:23Z","timestamp":1722440603000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unrivalled Insight into Possible Biopharmaceutical Application of\n                    <i>Justicia vahlii<\/i>\n                    Roth. (Acanthaceae): Chemodiversity, In Vitro Bioactivities, and Computational Analysis"],"prefix":"10.1002","volume":"21","author":[{"given":"Abdul","family":"Basit","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy The Islamia University of Bahawalpur  Bahawalpur, Punjab 63100 Pakistan"},{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmaceutical Sciences Prince of Songkla University  Hat Yai 90010, Songkhla Thailand"},{"name":"Drug Delivery System Excellence Center, Faculty of Pharmaceutical Sciences Prince of Songkla University  Hat Yai 90010, Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy The Islamia University of Bahawalpur  Bahawalpur, Punjab 63100 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitchamai","family":"Ovatlarnporn","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmaceutical Sciences Prince of Songkla University  Hat Yai 90010, Songkhla Thailand"},{"name":"Drug Delivery System Excellence Center, Faculty of Pharmaceutical Sciences Prince of Songkla University  Hat Yai 90010, Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Adeel","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmaceutical and Allied Health Science Lahore College for Women University  Lahore 51000 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Farrukh","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy The Islamia University of Bahawalpur  Bahawalpur, Punjab 63100 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umair","family":"Khurshid","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy The Islamia University of Bahawalpur  Bahawalpur, Punjab 63100 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hammad","family":"Saleem","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences (IPS) University of Veterinary &amp;Animal Sciences (UVAS)  Lahore 51000 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kashif ur Rehman","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy The Islamia University of Bahawalpur  Bahawalpur, Punjab 63100 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safiullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Cadson College of Pharmacy  Kharian, Punjab 50090 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamad M.","family":"Alkahtani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry College of Pharmacy King Saud University, P.O. 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