{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:30:58Z","timestamp":1789140658875,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Baccharis mattogrosensis<\/jats:italic> is a species from Asteraceae which has been used in Brazilian folk medicine to treatment of several illnesses, including those caused by parasites. In the present work, the MeOH extract of aerial parts of <jats:italic>B. mattogrosensis<\/jats:italic> was subjected to chromatographic fractionation to afford three flavonoids: apigenin (<jats:bold>1<\/jats:bold>), quercetin (<jats:bold>2<\/jats:bold>), and kaempferol (<jats:bold>3<\/jats:bold>) as well as a mixture three chlorogenic acids: 3,4\u2010O\u2010dicaffeoylquinic (<jats:bold>4<\/jats:bold>), 3,5\u2010O\u2010dicaffeoylquinic (<jats:bold>5<\/jats:bold>), and 4,5\u2010O\u2010dicaffeoylquinic (<jats:bold>6<\/jats:bold>) acids. When tested <jats:italic>in\u2005vitro<\/jats:italic>, kaempferol (<jats:bold>3<\/jats:bold>) exhibited activity against <jats:italic>Schistosoma mansoni<\/jats:italic> with EC<jats:sub>50<\/jats:sub>=81.86\u2005\u03bcM, whereas compounds <jats:bold>1<\/jats:bold>, <jats:bold>2<\/jats:bold>, <jats:bold>4<\/jats:bold>\u2013<jats:bold>6<\/jats:bold> showed to be inactives. Considering this result, the effects of kaempferol (<jats:bold>3<\/jats:bold>) against <jats:italic>S. mansoni<\/jats:italic> infection using an experimental approach (<jats:italic>in\u2005vivo<\/jats:italic> assay) was tested at first time. Using a single oral dose (400\u2005mg\/kg) of kaempferol (<jats:bold>3<\/jats:bold>) to <jats:italic>S. mansoni<\/jats:italic>\u2010infected mice reduced the worm burden by 25.5\u2009%. Similarly, the number of eggs, which are responsible for a variety of pathologies and transmission of schistosomiasis, was decreased by 28.8\u2009% in treated mice. Collectively, although kaempferol (<jats:bold>3<\/jats:bold>) is partially active when administered orally in a mouse model of schistosomiasis, our results suggest that this compound could be, in future studies, administered in different forms, such as nanoformulation.<\/jats:p>","DOI":"10.1002\/cbdv.202401452","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T14:58:50Z","timestamp":1723561130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oral Administration of Kaempferol Isolated from <i>Baccharis Mattogrosensis<\/i> Enables <i>In Vivo<\/i> Activity Against <i>Schistosoma Mansoni<\/i>"],"prefix":"10.1002","volume":"21","author":[{"given":"Mara Marcia S.","family":"Albuquerque","sequence":"first","affiliation":[{"name":"Phytochemistry Laboratory Department of Health State University of Feira de Santana  44036\u2013900 Feira de Santana, BA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca Lustosa S. A.","family":"Luz","sequence":"additional","affiliation":[{"name":"Phytochemistry Laboratory Department of Health State University of Feira de Santana  44036\u2013900 Feira de Santana, BA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius C.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Research Center for Neglected Diseases Guarulhos University  07023\u2013070 Guarulhos, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Roquini","sequence":"additional","affiliation":[{"name":"Research Center for Neglected Diseases Guarulhos University  07023\u2013070 Guarulhos, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Umehara","sequence":"additional","affiliation":[{"name":"Center for Natural and Human Sciences Federal University of ABC  09210\u2013580 Santo Andre, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Research Center for Neglected Diseases Guarulhos University  07023\u2013070 Guarulhos, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexsandro","family":"Branco","sequence":"additional","affiliation":[{"name":"Phytochemistry Laboratory Department of Health State University of Feira de Santana  44036\u2013900 Feira de Santana, BA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1193-8374","authenticated-orcid":false,"given":"Jo\u00e3o Henrique G.","family":"Lago","sequence":"additional","affiliation":[{"name":"Center for Natural and Human Sciences Federal University of ABC  09210\u2013580 Santo Andre, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"1","volume":"76","author":"M\u00fcller J.","year":"2006","journal-title":"Syst. Bot. Monograp."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357044067"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-010-1771-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2011.11.002"},{"key":"e_1_2_9_5_1","first-page":"171","volume":"9","author":"Grecco S. S.","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"e_1_2_9_6_1","unstructured":"World Health Organization (WHO) Schistosomiasis2023.https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/schistosomiasis."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0013-8"},{"key":"e_1_2_9_8_1","unstructured":"World Health Organization (WHO). Ending the neglect to attain the sustainable development goals: a road map for neglected tropical diseases 2021.https:\/\/www.who.int\/publications\/i\/item\/9789240010352."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2017-0112"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix496"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1958-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.04.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0347819"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.1352"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.08.035"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.663"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.23"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002617"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.08.012"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003656"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2020.10.022"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113295"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113633"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104041"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2018.10.121"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2015.10.001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2011.649857"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2009-11-1207"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci300447c"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100604"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2020.105741"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7184"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196667"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c01050"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2020.105350"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.06.005"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2016.10.008"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.917363"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2022.2051477"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2021-0146"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.08.002"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026619666190620163237"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01372-20"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01208-19"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-020-04140-z"},{"key":"e_1_2_9_47_1","first-page":"397","volume":"14","author":"Katz N.","year":"1972","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.04.029"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202401452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T08:09:46Z","timestamp":1732349386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202401452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":48,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/cbdv.202401452"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202401452","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,24]]},"assertion":[{"value":"2024-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202401452"}}