{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:48:49Z","timestamp":1767919729249,"version":"3.49.0"},"reference-count":57,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The different parts of <jats:italic>Sorbus torminalis<\/jats:italic> (L.) Crantz are used in traditional medicine for various conditions such as cardiac diseases, cough, and diabetes, indicating its significant medicinal potential. Therefore, the current investigation aimed to reveal the phenolic composition of the poorly studied <jats:italic>S. torminalis<\/jats:italic> methanol extract of the bark, as well as its capacity to inhibit enzymes relevant to cardiovascular, neurodegenerative, and metabolic diseases. A total of 28 phenolic components, including 20 procyanidins aglycones (A\u2010 and B\u2010type), four procyanidin glycosides, catechin and its glycoside, and two (epi)catechin derivatives, were detected using LC\u2013MS. The contents of total polyphenols (6.22\u2009%), total tannins (3.04\u2009%), condensed tannins (0.70\u2009%), and total flavonoids (0.24\u2009%) were determined spectrophotometrically, highlighting the considerable phenolic richness of the examined plant material. The concentration\u2010dependent ability to inhibit \u03b1\u2010amylase (IC<jats:sub>50<\/jats:sub>=130\u2005\u03bcg\u2009\/mL), \u03b1\u2010glucosidase (IC<jats:sub>50<\/jats:sub>=312.13\u2005\u03bcg\u2009\/mL), acetylcholinesterase (IC<jats:sub>50<\/jats:sub>=156.46\u2005\u03bcg\u2009\/mL), butyrylcholinesterase (IC<jats:sub>50<\/jats:sub>=217.68\u2005\u03bcg\u2009\/mL), and angiotensin\u2010converting enzyme (IC<jats:sub>50<\/jats:sub>=36.77\u2005\u03bcg\u2009\/mL) was demonstrated <jats:italic>in vitro<\/jats:italic>. The <jats:italic>in silico<\/jats:italic> approach showed that catechin, procyanidin B2 and C1, <jats:italic>S. torminalis<\/jats:italic> bark constituents, can form stable complexes with the target enzymes but with different binding affinity. The results supported the medicinal potential of <jats:italic>S. torminalis<\/jats:italic> bark and significantly expanded our knowledge of its chemistry, justifying further research.<\/jats:p>","DOI":"10.1002\/cbdv.202401459","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T12:42:26Z","timestamp":1722429746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Enzyme Inhibitory Activities, Phenolic Profile, and <i>In Silico<\/i> Studies of <i>Sorbus torminalis<\/i> Tree Bark Methanol Extract"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7324-1647","authenticated-orcid":false,"given":"Jelena","family":"Radovi\u0107 Selgrad","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy University of Belgrade \u2013 Faculty of Pharmacy  Vojvode Stepe 450 11221 Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-9976","authenticated-orcid":false,"given":"Violeta","family":"Milutinovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy University of Belgrade \u2013 Faculty of Pharmacy  Vojvode Stepe 450 11221 Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Relja","family":"Suru\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy University of Banja Luka \u2013 Faculty of Medicine  Save Mrkalja 14 78000 Banja Luka Republic of Srpska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8663-6680","authenticated-orcid":false,"given":"Stevan","family":"Samard\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy University of Belgrade \u2013 Faculty of Pharmacy  Vojvode Stepe 450 11221 Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0110ur\u0111ica","family":"Kopanja","sequence":"additional","affiliation":[{"name":"Mega Trade System d.o.o.  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