{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:37:19Z","timestamp":1778830639841,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QH153"],"award-info":[{"award-number":["ZR2023QH153"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Yellow River Delta possesses lots of characteristic medicinal plants due to its high salinity and high alkaline environment and <jats:italic>Limonium sinense<\/jats:italic> is an iconic plant. However, there are very few studies on <jats:italic>L. sinense<\/jats:italic> and its chemical constituents have not been investigated in recent ten years. In the present study, the chemical constituents and bioactivities of <jats:italic>L. sinense<\/jats:italic> were fully studied for the first time. UPLC\u2010MS\/MS method combined with database comparison identified 109 compounds mainly including flavonoids, alkaloids and polyphenols. In addition, the potential bioactivities of <jats:italic>L. sinense<\/jats:italic> were considerated as anti\u2010inflammatory, anti\u2010oxidative, anti\u2010tumor, hepatoprotective and hpyerglycemic activities based on these identified compounds and their related literature. Furthermore, four derivatives of 12\u2010oxo\u2010phytodienoic acid and butenolide including two new ones (<jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold>) were isolated from the whole plants of <jats:italic>L. sinense<\/jats:italic>. Their structures, including the absolute configurations, were determined by the analysis of comprehensive spectroscopic data. All isolates were evaluated for their anti\u2010inflammatory activity. Compound <jats:bold>1<\/jats:bold> exhibited moderate anti\u2010inflammatory activity with IC<jats:sub>50<\/jats:sub> value of 37.5\u00b11.2\u2005\u03bcM on NO production level.<\/jats:p>","DOI":"10.1002\/cbdv.202401514","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T01:58:06Z","timestamp":1725674286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chemical Constituents from the Whole Plants of <i>Limonium sinense<\/i> and Their <i>In\u2005Vitro<\/i> Anti\u2010Inflammatory Activity"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-712X","authenticated-orcid":false,"given":"Shi\u2010Zhou","family":"Qi","sequence":"first","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan 250355 China"},{"name":"Medical Research Center Binzhou Medical University Hospital  Yellow River Second Road 661 Binzhou 256603 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gao\u2010Feng","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Binzhou Medical University Hospital  Binzhou 256603 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Miao","sequence":"additional","affiliation":[{"name":"Medical Research Center Binzhou Medical University Hospital  Yellow River Second Road 661 Binzhou 256603 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Yuan","family":"Lv","sequence":"additional","affiliation":[{"name":"Medical Research Center Binzhou Medical University Hospital  Yellow River Second Road 661 Binzhou 256603 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si\u2010Qi","family":"Ren","sequence":"additional","affiliation":[{"name":"Medical Research Center Binzhou Medical University Hospital  Yellow River Second Road 661 Binzhou 256603 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Kai","family":"Gong","sequence":"additional","affiliation":[{"name":"Medical Research Center Binzhou Medical University Hospital  Yellow River Second Road 661 Binzhou 256603 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8567-6750","authenticated-orcid":false,"given":"Yong\u2010Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan 250355 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Binzhou Medical University Hospital  Binzhou 256603 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"244","volume":"25","author":"Liu Q.","year":"2023","journal-title":"Mod. 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