{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:16:11Z","timestamp":1782742571890,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nonalcoholic fatty liver disease (NAFLD) is closely related to gut microbiota due to the hepatic portal system, and utilizing natural polysaccharides as prebiotics has become a prospective strategy for treating NAFLD. However, the therapeutic effects and potential molecular mechanisms of Lanzhou Lily polysaccharides (LLP) on NAFLD remains unclear. Therefore, the alleviating effects of LLP on NAFLD induced by high\u2010fat diet (HFD) were investigated. LLP treatment greatly ameliorated NAFLD by significantly reducing lipid accumulation and the levels of liver function markers in HFD\u2010induced NAFLD mice, as evidenced by decreased serum levels of TG, TC, HDL\u2010C and LDL\u2010C. Furthermore, LLP administration reduced hepatic steatosis, as shown by H&amp;E and Oil red O staining. LLP also inhibited the TNF\u2010\u03b1 and IL\u20101\u03b2 expression, thereby reducing levels of hepatic proinflammatory cytokines. Furthermore, LLP restored gut microbiota dysbiosis (up\u2010regulated <jats:italic>Bacteroidota<\/jats:italic>, <jats:italic>Proteobacteria<\/jats:italic>, <jats:italic>Alistipes<\/jats:italic> and <jats:italic>Lachnospiraceae<\/jats:italic> abundances, down\u2010regulated <jats:italic>Firmicutes<\/jats:italic>, <jats:italic>Verrucomicrobiota<\/jats:italic>, <jats:italic>Desulfobacterota<\/jats:italic> and <jats:italic>Turicibacter<\/jats:italic> abundances), and regulated microbial metabolic pathways such as primary bile acid biosynthesis and amino acid metabolism. In addition, the resultes of Spearman's correlation analysis found that some key metabolites in these metabolic pathways were associated with intestinal microorganisms such as <jats:italic>Desulfobacterota<\/jats:italic>, <jats:italic>Prevotellaceae<\/jats:italic>\u2010UCG\u2010001, <jats:italic>Colidextribacter<\/jats:italic> and <jats:italic>Alistipes<\/jats:italic>. Therefore, our study suggests that LLP may has potential applications in the treatment of NAFLD by regulating gut microbiota and its metabolite profile.<\/jats:p>","DOI":"10.1002\/cbdv.202401538","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T19:03:46Z","timestamp":1725995026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Polysaccharides from Lanzhou Lily Attenuate Nonalcoholic Fatty Liver Disease Modifying the Gut Microbiota and Metabolite Profile"],"prefix":"10.1002","volume":"22","author":[{"given":"Zhengdou","family":"Li","sequence":"first","affiliation":[{"name":"College of Life Science Northwest Normal University  Lanzhou 730070 Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3563-0678","authenticated-orcid":false,"given":"Xueqi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Science Northwest Normal University  Lanzhou 730070 Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Science Northwest Normal University  Lanzhou 730070 Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Science Northwest Normal University  Lanzhou 730070 Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cancan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Science Northwest Normal University  Lanzhou 730070 Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Mao","sequence":"additional","affiliation":[{"name":"College of Life Science Northwest Normal University  Lanzhou 730070 Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixiang","family":"Teng","sequence":"additional","affiliation":[{"name":"Gansu Jingbo Biotechnology Development Co., LTD  Lanzhou 730070 Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinliang","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Life Science Northwest Normal University  Lanzhou 730070 Gansu Province China"},{"name":"Institute of Rural Development and Research Northwest Normal University  Lanzhou 730070 Gansu Province China"},{"name":"Bioactive Products Engineering Research Center for Gansu Distinctive Plants  Lanzhou 730070 Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9272-5243","authenticated-orcid":false,"given":"Ji","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Science Northwest Normal University  Lanzhou 730070 Gansu Province China"},{"name":"Institute of Rural Development and Research Northwest Normal University  Lanzhou 730070 Gansu Province China"},{"name":"Bioactive Products Engineering Research Center for Gansu Distinctive Plants  Lanzhou 730070 Gansu Province China"},{"name":"Gansu Provincial Association of Women Science and Technology Workers  Lanzhou 730070 Gansu Province China"},{"name":"Gansu Jingbo Biotechnology Development Co., LTD  Lanzhou 730070 Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110806"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.859206"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11123067"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.10.014"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203460"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.09.007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","unstructured":"C. Liu H. Hua H.\u2005K. Zhu et\u2005al. Int. J. Biol. Macromol.2021 185 804-812.","DOI":"10.1016\/j.ijbiomac.2021.07.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.10613"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227921"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2022.105071"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2016.03.030"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X16500269"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2010.08.056"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(87)80147-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109252"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO01611B"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-018-2750-2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786410903182212"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2023.112563"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7334"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.854674"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2019.07.001"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2020.01.009"},{"issue":"12","key":"e_1_2_10_24_1","first-page":"62","volume":"20","author":"Wang Y. Y.","year":"2020","journal-title":"J. Chin. Inst. Food Sci. Technol."},{"issue":"6","key":"e_1_2_10_25_1","first-page":"2325","volume":"49","author":"Huang Y. Y.","year":"2022","journal-title":"Microbiology Bul."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.055"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800100-4.00003-9"},{"issue":"4","key":"e_1_2_10_28_1","first-page":"1","volume":"5","author":"Morenoindias I.","year":"2014","journal-title":"Front. Microbiol."},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28356"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i23.6654"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b02979"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26093"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151829"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7261619"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v11.i8.619"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.788558"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13072135"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.01.005"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202401538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T17:42:31Z","timestamp":1737135751000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202401538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/cbdv.202401538"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202401538","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,14]]},"assertion":[{"value":"2024-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202401538"}}