{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:22:31Z","timestamp":1784852551246,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Purpose<\/jats:bold>\n                    : To evaluate the antidiabetic effect of\n                    <jats:italic>p<\/jats:italic>\n                    \u2010anisic acid (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010AA) against type 2 diabetes mellitus (T2DM).\n                    <jats:bold>Methods<\/jats:bold>\n                    : Thirty\u2010six male rats were utilized for the study. The animals were provided with the high\u2010fat diet (HFD) and T2DM was induced through 35\u2005mg\/kg streptozotocin (STZ). Subsequently, the animals were allocated to 6 groups and subjected to the treatments for 4\u2005weeks followed by a 2\u2010week observation. Three treatment groups were administered with\n                    <jats:italic>p<\/jats:italic>\n                    \u2010AA (25\u2005mg\/kg, 50\u2005mg\/kg or 100\u2005mg\/kg). Glibenclamide (3\u2005mg\/kg) was provided to the standard control group. The normal control and disease control groups were supplied with 0.1\u2009% carboxymethyl cellulose (CMC). Subsequently, the effects of treatment on body weight (BW), blood glucose level (BGL), glycosylated haemoglobin (HbA1c), insulin, and lipid parameters were measured and the pancreas was isolated for histopathology.\n                    <jats:bold>Results<\/jats:bold>\n                    : A statistically significant (\n                    <jats:italic>P<\/jats:italic>\n                    \u2010value&lt;0.001) increase in BW was observed in the\n                    <jats:italic>p<\/jats:italic>\n                    \u2010AA (50\u2005mg\/kg and 100\u2005mg\/kg) groups. The BGL decreased significantly (\n                    <jats:italic>P<\/jats:italic>\n                    \u2010value&lt;0.001) in\n                    <jats:italic>p<\/jats:italic>\n                    \u2010AA groups.\n                    <jats:italic>p<\/jats:italic>\n                    \u2010AA significantly (\n                    <jats:italic>P<\/jats:italic>\n                    \u2010value&lt;0.001) regulated the levels of HbA1c and serum insulin and lipid parameters. A notable improvement in the morphology of the pancreas was observed.\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : Treatment with\n                    <jats:italic>p<\/jats:italic>\n                    \u2010AA exhibited significant antidiabetic effects against STZ\u2010HFD\u2010induced T2DM.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401575","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T02:44:25Z","timestamp":1724985865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010Diabetic and Insulinotropic Effects of\n                    <i>p<\/i>\n                    \u2010Anisic Acid in High\u2010Fat Diet and Streptozotocin Induced Type\u20102 Diabetic Rats"],"prefix":"10.1002","volume":"21","author":[{"given":"Vishal","family":"Vora","sequence":"first","affiliation":[{"name":"Research Scholar, School of Pharmacy RK University  Rajkot, Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Tirgar","sequence":"additional","affiliation":[{"name":"Director, School of Pharmacy RK University  Rajkot, Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4114-0352","authenticated-orcid":false,"given":"Keval","family":"Raval","sequence":"additional","affiliation":[{"name":"Assistant Professor, Ramanbhai Patel College of Pharmacy Charotar University of Science and Technology  CHARUSAT Campus Changa, Anand, Gujarat 388421 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00690-7"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21642850.2024.2324091"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2021.10.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.03.014"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00634-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000380"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-022-04028-x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14662"},{"issue":"8","key":"e_1_2_11_9_1","volume":"15","author":"Sugandh F.","year":"2023","journal-title":"Cureus."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150710145753"},{"issue":"9","key":"e_1_2_11_11_1","volume":"9","author":"Vos R. 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