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Chemical profiling of the methanol extract of the defatted leaf revealed the presence of amentoflavone (<jats:bold>1<\/jats:bold>) as one of the constituents along with coumarins, terpenoids, steroids, and apetalic acids. Structural determination of amentoflavone (<jats:bold>1<\/jats:bold>) has been conducted by chemical, spectral, and spectrometric methods in comparison with spectral values available in the literature and confirmed by a single crystal X\u2010ray diffraction study. Amentoflavone (<jats:bold>1<\/jats:bold>) and its derivative (<jats:bold>2<\/jats:bold>\u2013<jats:bold>5<\/jats:bold>) tested to check the efficacy of anti\u2010malarial activity against <jats:italic>Plasmodium falciparum<\/jats:italic>. Amongst them, only tetra methoxy amentoflavone, (<jats:bold>2<\/jats:bold>) exhibited moderate anti\u2010malarial activity with <jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub> value 1.99\u00b10.42\u2005\u03bcM against <jats:italic>Plasmodium falciparum<\/jats:italic> in comparison with artemisinin as control, whereas the other products possessed almost negligible activity although their structural skeletons are identical with little variation of number and nature of substituents. The structure activity relationship (SAR) of the active constituent and its derivatives is reported herein.<\/jats:p>","DOI":"10.1002\/cbdv.202401576","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T14:03:48Z","timestamp":1728914628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti\u2010Malarial Activity of Amentoflavone Isolated from Leaf of <i>Calophyllum Tomentosum<\/i> Wight"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0941-5638","authenticated-orcid":false,"given":"Ajoy K.","family":"Bauri","sequence":"first","affiliation":[{"name":"Bio-Organic Division Bhabha Atomic Research Centre  Trombay, Mumbai 400085 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua H.","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Center for Tropical and Emerging Global Diseases (CTEGD) University of Georgia  Athens, GA 30602 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-3169","authenticated-orcid":false,"given":"Maria B.","family":"Cassera","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Center for Tropical and Emerging Global Diseases (CTEGD) University of Georgia  Athens, GA 30602 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8341-0205","authenticated-orcid":false,"given":"Sabine","family":"Foro","sequence":"additional","affiliation":[{"name":"Institute of Materials Science Darmstadt University of Technology  Alarich-Weiss-Strasse 2 D-64287 Darmstadt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"The Plant List. 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