{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T21:21:49Z","timestamp":1774473709707,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rheumatoid arthritis is an autoimmune disease mainly affecting the joints categorized by inflammation, swelling of the synovium and decrease in the joint movement. Bakuchiol, a meroterpene class of natural product present in <jats:italic>Psoralea corylifolia<\/jats:italic> known to possess anti\u2010inflammatory effects by a variety of mechanisms. However, its effects in rheumatoid arthritis still remain unclear. In the present investigation, we studied the anti\u2010arthritic effects of bakuchiol <jats:italic>via in silico<\/jats:italic> and <jats:italic>in\u2005vivo<\/jats:italic> experiments. It also showed antioxidant effects measured using DPPH assay where it showed free radical scavenging activity with IC<jats:sub>50<\/jats:sub> value 468.26\u2005\u03bcg\/ml. Molecular Docking studies carried out on COX\u20101 (PDB ID: 3\u2005N8Z), COX\u20102 (PDB ID: 4PH9) and TNF\u2010\u03b1 (PDB ID: 7JRA), proteins involved in inflammation in arthritis. Bakuchiol showed the maximum binding affinity for TNF\u2010\u03b1 with binding affinity score is \u22127.29\u2005kcal\/moland less affinity was observed for COX\u20101 and 2. <jats:italic>In vivo<\/jats:italic> antiarthritic effects were studied in arthritic female wistar rats model prepared by intradermal injection of freund's complete adjuvant. Bakuchiol was administered orally at dose of 10,20 and 40\u2005mg\/kg for 21\u2005days. Our treatment showed that bakuchiol at 20 and 40\u2005mg\/kg exhibited significant anti\u2010inflammatory effects (<jats:italic>p<\/jats:italic>&lt;0.001) showed by significant decrease in paw volume, paw diameter, spleen and thymus weight and increase in pain threshold and body weight in arthritic rat model. A significant decrease in hematological parameters such as total leukocyte count (TLC), platelet count, CRP and rheumatoid arthritis factor (RF) and increase in red blood cells count, ESR and hemoglobin further demonstrated that bakuchiol treatment suppresses the progression of adjuvant induced arthritis (AIA) in arthritic rat model. Histological analysis further revealed that bakuchiol ameliorates the pathological manifestations of AIA and reverse the abnormality induced by AIA in rats shown by protection against bone necrosis involved with low influx of inflammatory cells. Therefore, <jats:italic>in silico<\/jats:italic> and <jats:italic>in\u2005vivo<\/jats:italic> results revealed that bakuchiol has the potential to be developed as potent antiarthritic agent.<\/jats:p>","DOI":"10.1002\/cbdv.202401606","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T05:43:56Z","timestamp":1726119836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>In Silico<\/i> and <i>In Vivo<\/i> Evaluation of Anti\u2010Arthritic Effects of Bakuchiol from <i>Psoralea corylifolia<\/i> Seeds in Experimental Rat Model"],"prefix":"10.1002","volume":"22","author":[{"given":"Kamal","family":"Saini","sequence":"first","affiliation":[{"name":"M. M. College of Pharmacy Maharishi Markandeshwar (Deemed to be University)  Mullana-Ambala, Haryana India 133207"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samrat","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy Chitkara University  Rajpura, Punjab India 140401"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Ovais","family":"Dar","sequence":"additional","affiliation":[{"name":"M. M. College of Pharmacy Maharishi Markandeshwar (Deemed to be University)  Mullana-Ambala, Haryana India 133207"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumeet","family":"Gupta","sequence":"additional","affiliation":[{"name":"M. M. 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