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To investigate this, we examined the diuretic activity of RA alone and in combination with hydrochlorothiazide (HCTZ), amiloride (AML), atropine (ATR), and indomethacin (INDO) to see if any of these drugs could interfere with RA's activity in an 8\u2005hour acute diuresis animal model. We observed that RA increases urine excretion and may have a synergistic effect in the HCTZ+RA group, with a potassium\u2010sparing capacity. In the AML+RA group, we also noted increased urine excretion while sodium and potassium excretion decreased. ATR and INDO prevented RA from increasing urine excretion, suggesting a potential interaction with muscarinic receptors or a role in promoting prostaglandin production. Additionally, molecular docking analysis indicated possible interactions with key receptors involved in increased diuresis or free\u2010electrolyte water excretion.<\/jats:p>","DOI":"10.1002\/cbdv.202401634","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T14:43:44Z","timestamp":1729176224000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Involvement of Cholinergic and Cyclooxygenase Pathways in the Diuretic Effects of Rosmarinic Acid"],"prefix":"10.1002","volume":"22","author":[{"given":"Anelise","family":"Fel\u00edcio Macarini","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade do Vale do Itaja\u00ed  88302-901 - Itaja\u00ed, Santa Catarina Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00edsa Nathalia","family":"Bolda Mariano","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade do Vale do Itaja\u00ed  88302-901 - Itaja\u00ed, Santa Catarina Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"de C\u00e1ssia Vilhena da Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade do Vale do Itaja\u00ed  88302-901 - Itaja\u00ed, Santa Catarina Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade do Vale do Itaja\u00ed  88302-901 - Itaja\u00ed, Santa Catarina Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila","family":"de Souza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade do Vale do Itaja\u00ed  88302-901 - Itaja\u00ed, Santa Catarina Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1466252317000081"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1301-8648"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-022-01378-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122170"},{"key":"e_1_2_9_5_1","first-page":"260","volume":"64","author":"Ozturk H.","year":"2014","journal-title":"J. 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