{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:56Z","timestamp":1753862876304,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rice (<jats:italic>Oryza sativa<\/jats:italic> L.) husk harbors a substantial proportion of biological metabolites, as one of the most plentiful agriculture by\u2010products in rice milling process, rice husk remains poorly utilized. As a continuing search for potential bioactive molecules from the husk of rice, a totally of twelve components (<jats:bold>1<\/jats:bold>\u2013<jats:bold>12<\/jats:bold>), including six sterol ferulates (<jats:bold>1<\/jats:bold>\u2013<jats:bold>6<\/jats:bold>), one flavonoid (<jats:bold>7<\/jats:bold>), one dipeptide (<jats:bold>8<\/jats:bold>), and four phenylpropanoid derivatives (<jats:bold>9<\/jats:bold>\u2013<jats:bold>12<\/jats:bold>) were obtained. All the chemical structures were elucidated based on comprehensive spectroscopic data. Wherein, compounds <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> were yield as previous undescribed metabolites, and the comprehensive NMR data for compounds <jats:bold>3<\/jats:bold> and <jats:bold>4<\/jats:bold> were first presented in its entirety. Motivated by the similarity of the structural motifs of components <jats:bold>1<\/jats:bold>\u2013<jats:bold>6<\/jats:bold> to that of reported sterol ferulates, the antioxidant and anti\u2010inflammatory effects for compounds <jats:bold>1<\/jats:bold>\u2013<jats:bold>6<\/jats:bold> were evaluated in\u2005vitro. Among them, compounds <jats:bold>5<\/jats:bold>\/<jats:bold>6<\/jats:bold> had a significant antioxidant activity compare to that of vitamin E in both DPPH and reducing power assay up to the concentration 40\u2005\u03bcg\/ml; while compounds <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> exhibited weak suppressive effect on the production of nitric oxide, with the IC<jats:sub>50<\/jats:sub> values of 53.27\u00b11.37\u2005\u03bcM.<\/jats:p>","DOI":"10.1002\/cbdv.202401640","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T10:45:26Z","timestamp":1722509126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Specialized Metabolites from the Husks of Rice <i>Oryza Sativa<\/i> L. and their Biological Activities"],"prefix":"10.1002","volume":"21","author":[{"given":"Xue\u2010ying","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Pharmacy Nantong University  Nantong 226001 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Ge","sequence":"additional","affiliation":[{"name":"College of Pharmacy Nantong University  Nantong 226001 P. R. China"},{"name":"The First People's Hospital of Kunshan  Jiangsu 215300 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai\u2010ju","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Nantong University  Nantong 226001 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si\u2010xuan","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Nantong University  Nantong 226001 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Nantong University  Nantong 226001 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy First People's Hospital of Yancheng  Yancheng 224006 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6741-0982","authenticated-orcid":false,"given":"Jian Lin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Nantong University  Nantong 226001 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2014.08.002"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12540"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2014.10.023"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2021.2019733"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf062020b"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.879"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886-005-5290-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-2194(02)00063-7"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.11-87"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603539"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2023.105688"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/np049889d"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf000135o"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.08.095"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/np030020p"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","unstructured":"Z. Fang J. Fang C. Gao Y. Wu W. Yu BioMed Res. Int.2022 DOI:10.1155\/2022\/3510423.","DOI":"10.1155\/2022\/3510423"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.86"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcs.2012.01.005"},{"issue":"4","key":"e_1_2_11_19_1","first-page":"1","volume":"17","author":"Cai Y.-Y.","year":"2022","journal-title":"Nat. Prod. Commun."},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2021.1925893"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.112"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573406415666190708145639"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202401640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T08:10:42Z","timestamp":1732349442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202401640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/cbdv.202401640"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202401640","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"type":"print","value":"1612-1872"},{"type":"electronic","value":"1612-1880"}],"subject":[],"published":{"date-parts":[[2024,9,19]]},"assertion":[{"value":"2024-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202401640"}}