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Among these, compound <jats:bold>33<\/jats:bold> was isolated from this genus for the first time. The structures of these compounds were elucidated based on their physicochemical properties and spectroscopic data. The anti\u2010neuroinflammatory activities were assessed using LPS\u2010activated BV\u20102 microglial cells. Compounds <jats:bold>6<\/jats:bold>, <jats:bold>8<\/jats:bold>, <jats:bold>17<\/jats:bold>, <jats:bold>24<\/jats:bold>, <jats:bold>29<\/jats:bold>, and <jats:bold>30<\/jats:bold> exhibited significant inhibition of nitric oxide release in a dose\u2010dependent manner, with their inhibitory effects being 1.2 to 10.9 times greater than that of the positive control (minocycline).<\/jats:p>","DOI":"10.1002\/cbdv.202401653","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T07:24:35Z","timestamp":1728026675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Study on the Chemical Components and Anti\u2010Neuroinflammatory Activity of the Roots of <i>Clausena excavate<\/i> Burm. f."],"prefix":"10.1002","volume":"22","author":[{"given":"Yingjie","family":"Wang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City Shenyang Pharmaceutical University  Shenyang 110016 P.R. 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