{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:08:26Z","timestamp":1788246506025,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104524"],"award-info":[{"award-number":["82104524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Glaucic acid isolated from the root of\n                    <jats:italic>Lindera glauca<\/jats:italic>\n                    , was investigated by the biotransformation methods via the endophytic fungi, resulting in the production of five new glausesquiterpenes A\u2013E (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>5<\/jats:bold>\n                    ), along with a known analogue\n                    <jats:bold>6<\/jats:bold>\n                    . Their structures were elucidated based on spectroscopic methods and electronic circular dichroism (ECD) calculations. In the bioassays, glausesquiterpene A (\n                    <jats:bold>1<\/jats:bold>\n                    ) showed good inhibitory activity of NO production in LPS\u2010activated RAW 264.7 macrophages with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 20.1\u2005\u03bcM than positive control (Indomethacin, IC\n                    <jats:sub>50<\/jats:sub>\n                    24.1\u2005\u03bcM). Further\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    studies demonstrated that glausesquiterpene A significantly suppressed the protein expression of iNOS and COX\u20102 at the concentration of 25.0\u2005\u03bcM.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401658","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T01:45:05Z","timestamp":1723686305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biotransformation of Glaucic Acid Isolated from the Root of\n                    <i>Lindera glauca<\/i>\n                    by the Endophytic Fungi\n                    <i>Penicillium Chrysogenum<\/i>\n                    SHJ\u201007"],"prefix":"10.1002","volume":"21","author":[{"given":"Qinghui","family":"Zou","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou 510006 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqin","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou 510006 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou 510006 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anni","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou 510006 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"He","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou 510006 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongling","family":"Long","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou 510006 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4281-016X","authenticated-orcid":false,"given":"Hui","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou 510006 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yena","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-Sen University Cancer Center  Guangzhou 510060 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/b908720f"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b03595"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.7b00690"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/md15070229"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201033489847"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b02819"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b03573"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104871"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC09159A"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c01364"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b04648"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/np500077z"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202401658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202401658","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202401658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:14:34Z","timestamp":1773227674000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202401658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,21]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/cbdv.202401658"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202401658","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,21]]},"assertion":[{"value":"2024-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202401658"}}