{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:37:18Z","timestamp":1790869038140,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018996","name":"Hellenic Academic Libraries Link","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    HIV\u20101 remains a major health problem worldwide since the virus has developed drug\u2010resistant strains, so, the need for novel agents is urgent. The protein reverse transcriptase plays fundamental role in the viruses\u2019 replication cycle. FDA approved Delavirdine bearing a sulfonamide moiety, while thiazolidinone has demonstrated significant anti\u2010HIV activity as a core heterocycle or derivative of substituted heterocycles. In this study, thirty new thiazolidinone derivatives (series A, B and C) bearing sulfonamide group were designed, synthesized and evaluated for their HIV\u20101 RT inhibition activity predicted by computer program PASS taking into account the best features of available NNRTIs as well as against SARS\u2010COV\u20102 main protease. Seven compounds showed good anti\u2010HIV inhibitory activity, with two of them, C1 and C2 being better (IC\n                    <jats:sub>50<\/jats:sub>\n                    0.18\u2005\u03bc\u039c &amp; 0.12\u2005\u03bc\u039c respectively) than the reference drug nevirapine (IC\n                    <jats:sub>50<\/jats:sub>\n                    0.31\u2005\u03bc\u039c). The evaluation of molecules to inhibit the main protease revealed that 6 of the synthesized compounds exhibited excellent to moderate activity with two of them (B4 and B10) having better IC\n                    <jats:sub>50<\/jats:sub>\n                    values (0.15 &amp; 0.19\u2005\u03bc\u039c respectively) than the reference inhibitor GC376 (IC\n                    <jats:sub>50<\/jats:sub>\n                    0.439\u2005\u03bc\u039c). The docking studies is coincides with experimental results, showing good binding mode to both enzymes.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401697","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T16:09:02Z","timestamp":1729699742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Design, Synthesis, Biological Evaluation and Molecular Docking Studies of New Thiazolidinone Derivatives as NNRTIs and SARS\u2010CoV\u20102 Main Protease Inhibitors"],"prefix":"10.1002","volume":"21","author":[{"given":"Maria","family":"Fesatidou","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmacy Aristotle University of Thessaloniki  Thessaloniki 54124 Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthi","family":"Petrou","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmacy Aristotle University of Thessaloniki  Thessaloniki 54124 Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9894-7777","authenticated-orcid":false,"given":"Athina","family":"Geronikaki","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmacy Aristotle University of Thessaloniki  Thessaloniki 54124 Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuac040"},{"key":"e_1_2_9_2_1","unstructured":"UNAIDS\/WHO estimates 2023 HIV data and statistics.https:\/\/www.who.int\/teams\/global-hiv-hepatitis-and-stis-programmes\/hiv\/strategic-information\/hiv-data-and-statistics."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.11.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14372"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2023.2289709"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.ed.23.2.harv"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14051027"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.01.003"},{"issue":"3601764","key":"e_1_2_9_9_1","first-page":"22","volume":"2023","author":"Salubi C. 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