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Tryptamine was used as a source of indole pattern, as well as an example of biogenic amines which chemical transformations lead to the compounds with prominent biological activities. The obtained results for antimicrobial activity against a range of bacterial and fungal strains and cytotoxic activities have revealed that Schiff base <jats:bold>TSB4<\/jats:bold> combining the tryptamine and p\u2010nitro aryl patterns in the structure showed better antifungal activity at low concentrations than standard drug Fluconazole, while compound <jats:bold>TSB6<\/jats:bold> with molecular scaffold composed from tryptamine and quinoline moieties showed certain cytotoxic effect on HCT\u2010116\u2005cell line with a strongly expressed selectivity about healthy fibroblast cells, MRC\u20105. For these two selected compounds, additional ADME analysis and DNA interactions were performed. to obtain better insight into their pharmacokinetics and determination of binding mode for DNA molecules. As results suggested, strong binding of examined compounds to CT\u2010DNA was observed, while the ADME screening showed that selected compounds possess suitable physicochemical properties for oral bioavailability and druglikeness.<\/jats:p>","DOI":"10.1002\/cbdv.202401699","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T18:59:49Z","timestamp":1730141989000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tryptamine\u2010Derived Schiff Bases: Potent Antimicrobial Agents and Evaluation of Cytotoxicity, ADME and DNA Binding Properties"],"prefix":"10.1002","volume":"22","author":[{"given":"Jovana S.","family":"Marjanovi\u0107","sequence":"first","affiliation":[{"name":"University of Kragujevac Faculty of Science Department of Chemistry  Radoja Domanovica 12 34 000 Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevena","family":"Petrovi\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac Faculty of Science Department of Biology and Ecology  34 000 Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijana","family":"Kosani\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac Faculty of Science Department of Biology and Ecology  34 000 Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Ko\u0161ari\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac Institute for Information Technologies, Jovana, Cviji\u0107a  bb 34 000 Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Miri\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac Institute for Information Technologies, Jovana, Cviji\u0107a  bb 34 000 Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevena","family":"Milivojevi\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac Institute for Information Technologies, Jovana, Cviji\u0107a  bb 34 000 Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina D.","family":"Kosti\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac Institute for Information Technologies, Jovana, Cviji\u0107a  bb 34 000 Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-9386","authenticated-orcid":false,"given":"Vera M.","family":"Divac","sequence":"additional","affiliation":[{"name":"University of Kragujevac Faculty of Science Department of Chemistry  Radoja Domanovica 12 34 000 Kragujevac Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2009.00204.x"},{"key":"e_1_2_9_2_1","volume-title":"in The biochemistry of foreign compounds","author":"Parke D. 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