{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T07:40:29Z","timestamp":1763106029976,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Helicteres angustifolia<\/jats:italic> L. (<jats:italic>H. angustifolia<\/jats:italic>), a well\u2010known traditional Chinese medicine, has been demonstrated to have hypoglycemic activity. We found that the EtOAc extract of <jats:italic>H. angustifolia<\/jats:italic> (HAEF) showed stronger <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase inhibitory activity than that of positive control. Furthermore, the hypoglycemic activity of HAEF was evaluated in streptozotocin (STZ)\u2010induced type 2 diabetes mellitus (T2DM) rats. The results demonstrated that HAEF reduced the drinking quantity, feeding quantity, and controlled weight loss in diabetic rats. Besides, the fasting blood glucose (FBG), viscera index, and the area under time\u2010blood glucose curve (AUC) were significantly decreased, and the oral glucose tolerance was also improved after 5\u2005weeks. Then, the high\u2010performance liquid chromatography with quadrupole time of flight tandem mass spectrometry (HPLC\u2212Q\u2010TOF\u2010MS\/MS) method was performed for qualitative analysis of the chemical constituents in HAEF. Twenty\u2010one compounds were identified from in HAEF. Four compounds were further isolated from HAEF and subjected to <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase inhibition experiments. At the end, molecular docking was empolyed simulate the interaction of three compounds with <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase. This is the first report on major hypoglycaemic components has been identified in the roots of <jats:italic>H. angustifolia<\/jats:italic>. These findings provide a material basis for the use of <jats:italic>H. angustifolia<\/jats:italic> in the treatment of diabetes.<\/jats:p>","DOI":"10.1002\/cbdv.202401765","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T14:04:44Z","timestamp":1728137084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioactivity\u2010Based Analysis and Chemical Characterization of Hypoglycemic Components from <i>Helicteres angustifolia<\/i> L."],"prefix":"10.1002","volume":"22","author":[{"given":"Xiaoli","family":"Tian","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Pharmacy China Pharmaceutical University  639 Longmian Avenue Nanjing 211198 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Pharmacy China Pharmaceutical University  639 Longmian Avenue Nanjing 211198 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Pharmacy China Pharmaceutical University  639 Longmian Avenue Nanjing 211198 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Pharmacy China Pharmaceutical University  639 Longmian Avenue Nanjing 211198 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Pharmacy China Pharmaceutical University  639 Longmian Avenue Nanjing 211198 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidan","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Pharmacy China Pharmaceutical University  639 Longmian Avenue Nanjing 211198 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pensak","family":"Jantrawut","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Chiang Mai University  Chiang Mai 50200 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Yancheng Kanglinda Biotechnology Co., Ltd.  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