{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:54:17Z","timestamp":1791132857587,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Pluchea indica<\/jats:italic>\n                    (L.) Less. is a medicinal plant native to Asia. Traditionally, it is known for numerous traditional uses, such as treatments for fever, cough, and digestive issues. The present investigation aims to determine the chemical compositions of essential oils from its fresh leaves and stem barks. By using hydro\u2010distillation and the GC\u2010FID\/MS (gas chromatography\u2010flame ionization detection\/mass spectrometry) analysis, the studied samples were dominated by sesquiterpene hydrocarbons (76.8\u201382.2\u2009%) and their oxygenated derivatives (8.4\u201319.0\u2009%).\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010Selinene (42.0\u201343.5\u2009%) and silphinene (21.1\u201322.9\u2009%) were the main compounds. Significantly, the stem bark essential oil strongly monitored the growth of four cancer cell lines K562, HeLa, HepG2, and MCF\u20107 with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 2.89\u20137.34\u2005\u03bcg\/mL. Both studied samples showed strong anti\u2010inflammatory activity against NO (nitric oxide) production with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 21.81\u201323.18\u2005\u03bcg\/mL. The studied sample also exhibited antimicrobial activity at different levels. The molecular docking study revealed that\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010selinene exhibited the strongest binding affinity for all four cancer\u2010related protein targets: epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), Abelson tyrosine\u2013protein kinase 1 (ABL1), and phosphatidylinositol 3\u2010kinase (PI3\u2005K\u2010\u03b1). The ADMET profiles of the major compounds were also predicted to provide insights for further research considerations.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401785","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T07:19:00Z","timestamp":1725261540000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Essential Oils from the Leaves and Stem Barks of\n                    <i>Pluchea Indica<\/i>\n                    (L.) Less.: Chemical Analysis, Cytotoxicity, Anti\u2010inflammation, Antimicrobial Activity, Molecular Docking, and ADMET Profiling"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3504-6565","authenticated-orcid":false,"given":"Vu Minh","family":"Trang","sequence":"first","affiliation":[{"name":"VNU University of Education Vietnam National University,Hanoi  144 Xuan Thuy, Caugiay Hanoi 10000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninh The","family":"Son","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology (VAST)  18 Hoang Quoc Viet, Caugiay Hanoi 10000 Vietnam"},{"name":"Department of Chemistry Graduate University of Science and Technology, VAST  18 Hoang Quoc Viet, Caugiay Hanoi 10000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ty Viet","family":"Pham","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry University of Education Hue University  34 Le Loi Hue 530000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan Minh","family":"Giang","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry VNU University of Science Vietnam National University  19 Le Thanh Tong, Hoankiem Hanoi 10000 Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201200140"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2023.2234398"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5869"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2008.9700069"},{"key":"e_1_2_9_5_1","first-page":"425","volume":"4","author":"Madboly W. 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