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Their structures were elucidated using high\u2010resolution electrospray ionization mass spectrometry (HR\u2010ESI\u2010MS), infrared spectroscopy (IR), ultraviolet\u2010visible spectroscopy (UV), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) methods. All isolates were evaluated their anti\u2010inflammatory activity. The results indicated that compounds <jats:bold>1<\/jats:bold> and <jats:bold>6<\/jats:bold> inhibit lipopolysaccharide (LPS)\u2010induced nitric oxide production in RAW 264.7 macrophages with IC<jats:sub>50<\/jats:sub> values of 41.77\u00b11.80, 46.72\u00b11.75\u2005<jats:italic>\u03bc<\/jats:italic>mol\/L, respectively. Moreover, the potential targets of the four active ingredients were explored through network pharmacology, revealing that SRC, TP53, AKT1, and PIK3CA may serve as key anti\u2010inflammatory targets. 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