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This study presents nanoparticles developed from chitosan (CS), graphene oxide (GO), and magnetite (Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>), and their nanocomposites to enhance the loading and release efficiency of camptothecin (CPT). Nanostructures were characterized using imaging microscopy, FT\u2010IR, and X\u2010ray diffraction, with an average crystallite size of 5.5\u2005nm. Camptothecin binding proportions were 70\u2009% for CS, 81\u2009% for CS@Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>, 58\u2009% for CS@GO, and 74\u2009% for CS@GO\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>. At pH\u20055.0, CPT release ratios were 87\u2009%, 80\u2009%, 88\u2009%, and 90\u2009%, respectively, and at pH\u20057.4, 84\u2009%, 72\u2009%, 89\u2009%, and 87\u2009%. Cytotoxicity was assessed using the MTT assay against HepG2 and SMMC\u20107721 cancer cells. CPT\u2010CS@GO\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> exhibited the highest survival at 5\u2005\u03bcM and 12.5\u2005\u03bcM concentrations, indicating it as the most effective nanocarrier for camptothecin delivery. The study demonstrates CS@GO\/Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2032s potential as a superior drug delivery system.<\/jats:p>","DOI":"10.1002\/cbdv.202401817","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T07:23:41Z","timestamp":1728717821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Development of Chitosan\u2010Coated Graphene Oxide and Iron Oxide Nanocomposites for Targeted Delivery of Camptothecin to Liver Cancer Cells"],"prefix":"10.1002","volume":"22","author":[{"given":"Kalpana","family":"Sukumar","sequence":"first","affiliation":[{"name":"Department of Physics Saveetha Engineering College  Saveetha Nagar Thandalam, Chennai 602105 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muruganantham","family":"Bharathi","sequence":"additional","affiliation":[{"name":"Centre for Drug Discovery Department of Biochemistry Karpagam Academy of Higher Education  Coimbatore, Tamil Nadu 641021 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurahman Hajinur","family":"Hirad","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology College of Science King Saud University  P.O. 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