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The antifungal\/oomycete activity bioassay showed that some of the title compounds displayed moderate to good antifungal activity against <jats:italic>Botryosphaeria dothidea<\/jats:italic>, <jats:italic>Sclerotinia sclerotiorum<\/jats:italic>, and <jats:italic>Valsa mali<\/jats:italic>. Compound <jats:bold>4k<\/jats:bold> exhibited the best in vitro antifungal activity toward <jats:italic>V. mali<\/jats:italic>. The in vivo experiment identified that <jats:bold>4k<\/jats:bold> possessed considerable anti\u2010<jats:italic>V. mali<\/jats:italic> protective and curative effect at 200\u00a0mg\/L. Antifungal mechanism study showed that <jats:bold>4k<\/jats:bold> could destroy the morphology of <jats:italic>V. mali<\/jats:italic> mycelia, increase the cell membrane permeability, inhibit the dry weight of <jats:italic>V. mali<\/jats:italic> mycelia and lead to the increase of reactive oxygen species (ROS) level. The phytotoxicity experiment revealed that compound <jats:bold>4k<\/jats:bold> showed good safety on mung beans. These cuminic acid derivatives would be potential fungicides for controlling apple canker disease.<\/jats:p>","DOI":"10.1002\/cbdv.202401836","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T22:19:47Z","timestamp":1734301187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis and Antifungal\/Oomycetes Activity of Cuminic Acid Derivatives Containing Thiourea Group for Crop Protection"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-5107","authenticated-orcid":false,"given":"Zi Hui","family":"Yang","sequence":"first","affiliation":[{"name":"Academy of Science and Technology Chuxiong Normal University  Chuxiong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chemistry and Chemical Engineering College AnShun University  Anshun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10658-009-9521-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c01322"},{"key":"e_1_2_8_4_1","first-page":"549","article-title":"Screening Fungicide for Pathogen Inhibition and Disease Control of Apple Tree Valsa Canker","volume":"39","author":"Wang L.","year":"2009","journal-title":"Acta Phytopathologica Sinica"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-7348.1952.tb01072.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3186\/jjphytopath.48.490"},{"key":"e_1_2_8_7_1","first-page":"114","article-title":"Investigations on the Occurrence and Control of Apple Canker in China","volume":"35","author":"Cao K. 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