{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T19:49:56Z","timestamp":1776023396942,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Colorectal cancer is the second most common cause of cancer\u2010related death worldwide, with a rising incidence, highlighting an urgent need for novel therapeutics. In this study, we developed several polyamine conjugates. Compound <jats:bold>6<\/jats:bold> (<jats:bold>C6<\/jats:bold>) was selected as the lead compound and was evaluated for anticancer activity in vitro and in vivo. In vitro experiments showed that <jats:bold>C6<\/jats:bold> inhibited cell proliferation, colony formation, migration, and invasion of colorectal cancer cells while inducing apoptosis, pyroptosis, and autophagosome formation. Genetic or pharmacological inhibition of autophagy weakened <jats:bold>C6<\/jats:bold>\u2010induced apoptosis and gasdermin E (GSDME)\u2010dependent pyroptosis. Inactivation of caspase 3 activity by AC\u2010DEVD\u2010CHO decreased the levels of N\u2010terminal GSDME induced by <jats:bold>C6<\/jats:bold>. Furthermore, animal models exhibited suppressed tumor growth and dissemination after treatment with <jats:bold>C6<\/jats:bold>. Taken together, our findings highlight <jats:bold>C6<\/jats:bold> as a potential drug against colorectal cancer.<\/jats:p>","DOI":"10.1002\/cbdv.202401873","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T05:10:01Z","timestamp":1733375401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design, Synthesis, and Biological Evaluation of Naphthalimide\u2010Polyamine Conjugate as a Potential Anti\u2010Colorectal Cancer Agent"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1122-0327","authenticated-orcid":false,"given":"Fujun","family":"Dai","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng Henan China"},{"name":"The First Affiliated Hospital of Henan University Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Cao","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenguang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibing","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Henan University Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haizhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoya","family":"Xie","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0311-3330","authenticated-orcid":false,"given":"Lei","family":"Gao","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanming","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Henan University Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaojie","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Natural Medicine Innovation and Transformation Henan University  Kaifeng Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01294-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188623"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01508-w"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010426"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.782982"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00507-5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14225505"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.64350"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1441-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.713322"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-1812"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00473-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4274\/balkanmedj.galenos.2023.2023-3-102"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204038"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01846"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00694"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-018-0688-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000002511"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107731"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113078"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2038999"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1911017"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2022.12885"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114932"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2022.08.006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092004"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.10.004"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011488"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2023.101781"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154596"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22393"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1883-8"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222010987"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.10.069"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1653-7"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2239"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.06.015"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.809955"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01046-3"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.05.009"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.59546"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114758"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26030638"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.62521"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-022-00887-6"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02848-0"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.109967"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021110468"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.858494"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmaa097"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9925059"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2017.12.036"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202401873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T11:16:28Z","timestamp":1744888588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202401873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/cbdv.202401873"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202401873","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]},"assertion":[{"value":"2024-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202401873"}}