{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:06:05Z","timestamp":1753862765629,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP23\u2005K24040","23\u2005K06179"],"award-info":[{"award-number":["JP23\u2005K24040","23\u2005K06179"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Trichilia dregeana<\/jats:italic> Sond. (Meliaceae) is a plant used in traditional medicine to treat wounds. The anti\u2010inflammatory potential of the ethyl acetate leaf extract and the presence of euphane\u2010type triterpenes in this extract have recently been reported by our group. Further investigation of the remaining subfractions of the ethyl acetate fraction afforded a new 19(10\u21929)<jats:italic>abeo<\/jats:italic>\u2010euphane\u2010type triterpenoid (<jats:bold>1<\/jats:bold>), along with six known terpenoids (<jats:bold>2<\/jats:bold>\u2013<jats:bold>7<\/jats:bold>). The structure of the new compound was elucidated by analyses of the HR\u2010ESI\u2010MS, 1D and 2D NMR data and by comparison with previously reported data. We investigated the ability of the compounds to modulate the production of nitric oxide (NO) in LPS\u2010stimulated RAW264.7 macrophages. The known compounds <jats:bold>3<\/jats:bold> and <jats:bold>6<\/jats:bold> exhibited moderate (IC<jats:sub>50<\/jats:sub> 72.06\u2005\u03bcM) and mild (IC<jats:sub>50<\/jats:sub> 98.84\u2005\u03bcM) inhibitory activities, respectively, without cytotoxic effects on the cells. These results, in conjunction with our previous findings, emphasize the significant role of terpenoid components in the anti\u2010inflammatory efficacy of <jats:italic>T. dregeana<\/jats:italic> leaves and indicate that the rare 3,10\u2010epoxy\u201019(10\u21929)<jats:italic>abeo<\/jats:italic>\u2010euphane triterpenoids could serve as a chemotaxonomic marker for <jats:italic>T. dregeana<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cbdv.202401919","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T02:24:03Z","timestamp":1726712643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A New 19(10\u21929)<i>Abeo<\/i>\u2010Euphane Triterpenoid with other Terpenoid Components from <i>Trichilia dregeana<\/i> Leaves and their NO Production Inhibitory Activities in LPS\u2010Stimulated RAW264.7 Macrophages"],"prefix":"10.1002","volume":"22","author":[{"given":"Yves M.","family":"Mba Nguekeu","sequence":"first","affiliation":[{"name":"Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang  P.O. Box 67 Dschang Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kodama","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine University of Toyama  2630-Sugitani Toyama 930-0194 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zin","family":"Paing Htoo","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine University of Toyama  2630-Sugitani Toyama 930-0194 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie Ga\u00eble","family":"Matheuda","sequence":"additional","affiliation":[{"name":"Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang  P.O. Box 67 Dschang Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie G.","family":"Tsepeupon Matchide","sequence":"additional","affiliation":[{"name":"Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang  P.O. Box 67 Dschang Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silv\u00e8re","family":"Augustin Ngouela","sequence":"additional","affiliation":[{"name":"Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang  P.O. Box 67 Dschang Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Tene","sequence":"additional","affiliation":[{"name":"Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang  P.O. Box 67 Dschang Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4259-7103","authenticated-orcid":false,"given":"Maurice","family":"Ducret Awouafack","sequence":"additional","affiliation":[{"name":"Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang  P.O. Box 67 Dschang Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9963-0587","authenticated-orcid":false,"given":"Hiroyuki","family":"Morita","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine University of Toyama  2630-Sugitani Toyama 930-0194 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.7591"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/805756"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-007-0013-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.13490"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.33448\/rsd-v10i5.14916"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13020298"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3897\/BDJ.2.e1049"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2023.2297254"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2019.07.009"},{"key":"e_1_2_9_10_1","first-page":"607","volume":"27","author":"Legesse A.","year":"2023","journal-title":"J. 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